What drugs target Sigma non-opioid intracellular receptor 1?

13+ drugs target Sigma non-opioid intracellular receptor 1, including Aricept, GOCOVRI, Cefaprin, Aralen, Naftin.

What drug classes act on Sigma non-opioid intracellular receptor 1?

Drug classes acting on Sigma non-opioid intracellular receptor 1 include Cholinesterase Inhibitor, Influenza A M2 Protein Inhibitor, cefapirin, Antimalarial, Allylamine Antifungal.

Sigma non-opioid intracellular receptor 1 — Drug Target

13 drugs 7 marketed 2 in Phase 3

All drugs that target Sigma non-opioid intracellular receptor 1 — marketed and clinical-stage. Includes 12 drug classes acting on this target.

Drug classes

Cholinesterase Inhibitor · Influenza A M2 Protein Inhibitor · cefapirin · Antimalarial · Allylamine Antifungal · Central Nervous System Stimulant [EPC] · eperisone · opipramol · etilamfetamine · dimemorfan · dioxadrol · nepinalone

Marketed (7)

Aricept · Eisai · Cholinesterase Inhibitor · Neuroscience
Aricept works by blocking the enzyme that breaks down a key neurotransmitter in the brain, acetylcholine.
GOCOVRI · Oregon Health and Science University · Influenza A M2 Protein Inhibitor · Neuroscience
Cefaprin · Bristol-Myers Squibb · cefapirin · Metabolic
Aralen · Sanofi · Antimalarial · Immunology
Aralen works by accumulating in the acidic compartments of the malaria parasite, disrupting its metabolism and ultimately leading to its death.
Naftin · Legacy Pharma · Allylamine Antifungal · Infectious Disease
Naftin works by inhibiting the synthesis of ergosterol in fungal cell membranes.
Pentoxiverine · Central Nervous System Stimulant [EPC] · Respiratory
Gocovri · Endo · Influenza A M2 Protein Inhibitor · Immunology

Phase 3 pipeline (2)

(+/-)-Eperisone · eperisone · Pain
Eperisone works by binding to the Sigma non-opioid intracellular receptor 1, which helps to reduce muscle spasms.
Opramidol · opipramol · Neuroscience
Opipramol works by binding to the sigma non-opioid intracellular receptor 1, which helps to regulate mood and emotional responses.

Phase 2 pipeline (4)

Apetinil · etilamfetamine · Pain
Apetinil works by binding to the Sigma non-opioid intracellular receptor 1, which is involved in various physiological processes.
Dimemorphan · dimemorfan · Pain
Dimemorfan works by activating opioid receptors in the brain to reduce pain perception.
DIOXADROL · dioxadrol · Pain
DIOXADROL is a small molecule that works by interacting with a specific target, although the exact target and mechanism are unknown.
NEPINALONE · nepinalone · Pain
Nepinalone works by binding to the Sigma non-opioid intracellular receptor 1, which helps to reduce coughing.