Antimalarial
This page covers all Antimalarial drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Plasmodium falciparum, Adenosine receptor A2a, Potassium voltage-gated channel subfamily H member 2.
Targets
Plasmodium falciparum · Adenosine receptor A2a · Potassium voltage-gated channel subfamily H member 2 · Sigma non-opioid intracellular receptor 1 · Toll-like receptor 9 · Sodium channel alpha subunits; brain (Types I, II, III) · Plasmodium · Plasmodium parasites · Dihydropteroate synthase, Dihydrofolate reductase · Dihydroorotate dehydrogenase, Beta-hematin formation
Marketed (7)
- RIAMET (artemether + LUMEFANTRIN combination) · Assistance Publique - Hôpitaux de Paris · Metabolic
Riamet combines artemether, a fast-acting antimalarial, with lumefantrine, a longer-acting partner, to provide a synergistic effect against Plasmodium falciparum. - Lariam · Metabolic
- Halfan · GSK · Rare Disease
- Aralen · Sanofi · Immunology
Aralen works by accumulating in the acidic compartments of the malaria parasite, disrupting its metabolism and ultimately leading to its death. - Hydroxychloroquine Sulfate · Advanz · Immunology
Hydroxychloroquine Sulfate works by interfering with the replication of malaria parasites and reducing inflammation in the body. - Lariam · Metabolic
- Qualaquin · Sun Pharm Industries · Rare Disease
Phase 3 pipeline (17)
- hydroxychloroquine (Z0188) · Sanofi · Infectious Diseases
Hydroxychloroquine is an antimalarial drug that works by inhibiting the growth and replication of Plasmodium parasites in the red blood cells. - arthemeter-lumefantrin · University of Oxford · Infectious Diseases
Artemether-lumefantrin is a combination antimalarial drug that works by inhibiting the growth and replication of Plasmodium parasites. - sulfadoxine-pyrimethamine / mefloquine · Institut de Recherche pour le Developpement · Infectious Diseases
Sulfadoxine-pyrimethamine is a combination of a sulfonamide antibiotic and a dihydrofolate reductase inhibitor, while mefloquine is a blood schizonticide. - chloroquine, sulphadoxine pyrimethamine, LLIN · University of Melbourne · Infectious Diseases
Chloroquine works by inhibiting the growth of the malaria parasite in the red blood cells, while sulphadoxine pyrimethamine acts as a folate antagonist, disrupting the parasite's metabolism. - BPaQM · Otsuka Pharmaceutical Development & Commercialization, Inc. · Infectious Disease
BPaQM is a novel antimalarial compound that acts as a blood schizonticide to prevent malaria parasite multiplication in red blood cells. - SP + amodiaquine · London School of Hygiene and Tropical Medicine · Infectious Diseases
Sulfadoxine and pyrimethamine work by inhibiting dihydropteroate synthase and dihydrofolate reductase, respectively, disrupting folic acid synthesis in Plasmodium parasites. - Sulfadoxine pyrimethamine + Amodiaquin · University Clinical Research Center, Mali · Infectious Diseases
Sulfadoxine pyrimethamine is a combination of a sulfonamide antibiotic and a dihydrofolate reductase inhibitor, while amodiaquine is a 4-aminoquinoline antimalarial. - artesunate-sulphadoxin/pyrimethamine, chloroquine · University of Oxford · Infectious Diseases
Artesunate-sulphadoxin/pyrimethamine works by inhibiting the growth of malaria parasites, while chloroquine targets the parasite's digestive enzyme. - Pyronaridine-artesunate (PA) · Liverpool School of Tropical Medicine · Infectious Diseases
Pyronaridine-artesunate is a combination of pyronaridine and artesunate, which work together to inhibit the growth of malaria parasites. - amodiaquine+artesunate/artemether-lumefantrine · University of Ghana Medical School · Infectious Diseases
Amodiaquine is a chloroquine derivative that acts as an antimalarial agent by inhibiting the parasite's heme detoxification pathway, while artesunate and artemether-lumefantrine are artemisinin-based combination therapies that rapidly kill the parasite. - chlorproguanil-dapsone-artesunate · GlaxoSmithKline · Infectious Diseases
Chlorproguanil-dapsone-artesunate is a combination antimalarial medication that works by targeting the malaria parasite's metabolic pathways and disrupting its ability to synthesize nucleic acids. - SP plus amodiaquine · London School of Hygiene and Tropical Medicine · Infectious Diseases
SP plus amodiaquine is a combination antimalarial medication that works by targeting the malaria parasite's life cycle. - dihydroartemisinin plus piperaquine · London School of Hygiene and Tropical Medicine · Infectious Diseases
Dihydroartemisinin is a derivative of artemisinin that kills malaria parasites by generating free radicals, while piperaquine acts as a blood schizonticide. - sulfalene-pyrimethamine plus amodiaquine · London School of Hygiene and Tropical Medicine · Infectious Diseases
Sulfalene-pyrimethamine plus amodiaquine is an antimalarial combination that works by inhibiting the growth of the malaria parasite. - Sulphadoxine-pyrimethamine + amodiaquine + placebo azithromycin · London School of Hygiene and Tropical Medicine · Infectious Diseases
Sulphadoxine-pyrimethamine is a combination of a sulfonamide antibiotic and a dihydrofolate reductase inhibitor, while amodiaquine is an antimalarial drug that works by interfering with the parasite's ability to synthesize DNA and RNA. - Sulphadoxine-Pyrimethamine+ Amodiaquine+ Azithromycin · London School of Hygiene and Tropical Medicine · Infectious Diseases
Sulphadoxine acts as a sulfonamide antibacterial agent, inhibiting dihydropteroate synthase, while pyrimethamine inhibits dihydrofolate reductase, and amodiaquine is a 4-aminoquinoline antimalarial that targets the malaria parasite's heme detoxification pathway. Azithromycin is a macrolide antibiotic that inhibits protein synthesis in bacteria. - tablets artemether/lumefantrine · University of Khartoum · Infectious Diseases
Artemether/lumefantrine works by targeting the malaria parasite's cell membrane and disrupting its function, ultimately leading to the parasite's death.
Phase 2 pipeline (4)
- Artesunate vaginal insert · Frantz Viral Therapeutics, LLC · Infectious Disease
Artesunate is a derivative of artemisinin that targets the heme moiety of the malaria parasite, disrupting its 80-kDa protein. - Artefenomel-Ferroquine · Centre de Recherche Médicale de Lambaréné · Infectious Diseases
Artefenomel-Ferroquine is a combination of artefenomel and ferroquine, which targets the Plasmodium falciparum parasite. - Artesunate for Injection · U.S. Army Office of the Surgeon General · Infectious Disease
Artesunate for Injection works by inhibiting the growth of malaria parasites in the blood. - Eurartesim dispersible oral tablet · sigma-tau i.f.r. S.p.A. · Infectious Disease
Eurartesim is a fixed-dose combination of dihydroartemisinin and piperaquine, targeting the hemozoin formation in Plasmodium parasites to treat malaria.
Phase 1 pipeline (3)
- ASAQ Winthrop® Sanofi Aventis · Epicentre · Infectious Disease
Artemisinin and Amodiaquine combination - Artemether-lumefantrine: P. falciparum · Centers for Disease Control and Prevention · Infectious Disease
Artemether is a fast-acting antimalarial that acts by inhibiting the parasite's mitochondrial electron transport chain, while lumefantrine is a slow-acting antimalarial that acts by inhibiting the parasite's heme detoxification pathway. - Artemether-lumefantrine fixed combination · Epicentre · Infectious Disease
Artemether is a fast-acting antimalarial that acts by inhibiting the parasite's mitochondrial electron transport chain, while lumefantrine is a slow-acting antimalarial that acts by inhibiting the parasite's heme detoxification pathway.