Last reviewed · How we verify

chloroquine, sulphadoxine pyrimethamine, LLIN

University of Melbourne · Phase 3 active Small molecule

chloroquine, sulphadoxine pyrimethamine, LLIN is a Antimalarial Small molecule drug developed by University of Melbourne. It is currently in Phase 3 development for Malaria prevention and treatment. Also known as: sulfadoxine-pyrimethamine.

Chloroquine works by inhibiting the growth of the malaria parasite in the red blood cells, while sulphadoxine pyrimethamine acts as a folate antagonist, disrupting the parasite's metabolism.

Chloroquine works by inhibiting the growth of the malaria parasite in the red blood cells, while sulphadoxine pyrimethamine acts as a folate antagonist, disrupting the parasite's metabolism. Used for Malaria prevention and treatment.

At a glance

Generic namechloroquine, sulphadoxine pyrimethamine, LLIN
Also known assulfadoxine-pyrimethamine
SponsorUniversity of Melbourne
Drug classAntimalarial
ModalitySmall molecule
Therapeutic areaInfectious Diseases
PhasePhase 3

Mechanism of action

Chloroquine is a 4-aminoquinoline that accumulates in the acidic compartments of the malaria parasite, disrupting its digestive vacuole and ultimately leading to the parasite's death. Sulphadoxine pyrimethamine, on the other hand, inhibits dihydropteroate synthase, an enzyme crucial for the synthesis of folic acid in the parasite, thereby disrupting its metabolism and preventing it from replicating.

Approved indications

Common side effects

Key clinical trials

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

Frequently asked questions about chloroquine, sulphadoxine pyrimethamine, LLIN

What is chloroquine, sulphadoxine pyrimethamine, LLIN?

chloroquine, sulphadoxine pyrimethamine, LLIN is a Antimalarial drug developed by University of Melbourne, indicated for Malaria prevention and treatment.

How does chloroquine, sulphadoxine pyrimethamine, LLIN work?

Chloroquine works by inhibiting the growth of the malaria parasite in the red blood cells, while sulphadoxine pyrimethamine acts as a folate antagonist, disrupting the parasite's metabolism.

What is chloroquine, sulphadoxine pyrimethamine, LLIN used for?

chloroquine, sulphadoxine pyrimethamine, LLIN is indicated for Malaria prevention and treatment.

Who makes chloroquine, sulphadoxine pyrimethamine, LLIN?

chloroquine, sulphadoxine pyrimethamine, LLIN is developed by University of Melbourne (see full University of Melbourne pipeline at /company/university-of-melbourne).

Is chloroquine, sulphadoxine pyrimethamine, LLIN also known as anything else?

chloroquine, sulphadoxine pyrimethamine, LLIN is also known as sulfadoxine-pyrimethamine.

What drug class is chloroquine, sulphadoxine pyrimethamine, LLIN in?

chloroquine, sulphadoxine pyrimethamine, LLIN belongs to the Antimalarial class. See all Antimalarial drugs at /class/antimalarial.

What development phase is chloroquine, sulphadoxine pyrimethamine, LLIN in?

chloroquine, sulphadoxine pyrimethamine, LLIN is in Phase 3.

What are the side effects of chloroquine, sulphadoxine pyrimethamine, LLIN?

Common side effects of chloroquine, sulphadoxine pyrimethamine, LLIN include Nausea, Vomiting, Diarrhea, Headache, Dizziness.

Related