{"id":"chloroquine-sulphadoxine-pyrimethamine-llin","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Nausea"},{"rate":"5-10%","effect":"Vomiting"},{"rate":"5-10%","effect":"Diarrhea"},{"rate":"5-10%","effect":"Headache"},{"rate":"5-10%","effect":"Dizziness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Chloroquine is a 4-aminoquinoline that accumulates in the acidic compartments of the malaria parasite, disrupting its digestive vacuole and ultimately leading to the parasite's death. Sulphadoxine pyrimethamine, on the other hand, inhibits dihydropteroate synthase, an enzyme crucial for the synthesis of folic acid in the parasite, thereby disrupting its metabolism and preventing it from replicating.","oneSentence":"Chloroquine works by inhibiting the growth of the malaria parasite in the red blood cells, while sulphadoxine pyrimethamine acts as a folate antagonist, disrupting the parasite's metabolism.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:05:44.095Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Malaria prevention and treatment"}]},"trialDetails":[{"nctId":"NCT01136850","phase":"PHASE3","title":"Intermittent Preventive Treatment With Azithromycin-containing Regimens in Pregnant Women in Papua New Guinea","status":"COMPLETED","sponsor":"University of Melbourne","startDate":"2009-11","conditions":"Malaria in Pregnancy, Sexually Transmitted Infections, Anaemia","enrollment":2793}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["sulfadoxine-pyrimethamine"],"phase":"phase_3","status":"active","brandName":"chloroquine, sulphadoxine pyrimethamine, LLIN","genericName":"chloroquine, sulphadoxine pyrimethamine, LLIN","companyName":"University of Melbourne","companyId":"university-of-melbourne","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Chloroquine works by inhibiting the growth of the malaria parasite in the red blood cells, while sulphadoxine pyrimethamine acts as a folate antagonist, disrupting the parasite's metabolism. Used for Malaria prevention and treatment.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}