Last reviewed · How we verify
amodiaquine+artesunate/artemether-lumefantrine
amodiaquine+artesunate/artemether-lumefantrine is a Antimalarial Small molecule drug developed by University of Ghana Medical School. It is currently in Phase 3 development for Treatment of uncomplicated malaria, Treatment of severe malaria.
Amodiaquine is a chloroquine derivative that acts as an antimalarial agent by inhibiting the parasite's heme detoxification pathway, while artesunate and artemether-lumefantrine are artemisinin-based combination therapies that rapidly kill the parasite.
Amodiaquine is a chloroquine derivative that acts as an antimalarial agent by inhibiting the parasite's heme detoxification pathway, while artesunate and artemether-lumefantrine are artemisinin-based combination therapies that rapidly kill the parasite. Used for Treatment of uncomplicated malaria, Treatment of severe malaria.
At a glance
| Generic name | amodiaquine+artesunate/artemether-lumefantrine |
|---|---|
| Sponsor | University of Ghana Medical School |
| Drug class | Antimalarial |
| Target | Plasmodium heme detoxification pathway |
| Modality | Small molecule |
| Therapeutic area | Infectious Diseases |
| Phase | Phase 3 |
Mechanism of action
Amodiaquine's mechanism of action involves the inhibition of the parasite's heme detoxification pathway, which is essential for the parasite's survival. Artesunate and artemether-lumefantrine, on the other hand, rapidly kill the parasite by generating reactive oxygen species that damage the parasite's cell membrane.
Approved indications
- Treatment of uncomplicated malaria
- Treatment of severe malaria
Common side effects
- Nausea
- Vomiting
- Diarrhea
- Abdominal pain
- Headache
Key clinical trials
- OPTImizing Malaria And HIV Treatment in a Shifting Landscape in Africa (PHASE4)
- Health Systems Implementation and Molecular Surveillance of Multiple First-Line Treatments for Uncomplicated Malaria in Western Kenya
- A Study to Find Out if a Combination of 3 Medicines for the Treatment of Malaria Works as Well and is as Safe and Tolerable as Combinations of 2 Medicines (PHASE3)
- A Trial to Compare the Efficacy, Safety and Tolerability of Combinations of 3 Anti-malarial Drugs Against Combina-tions of 2 Anti-malarial Drugs. (PHASE3)
- In Vivo Efficacy of Artemether-Lumefantrine, Amodiaquine-Artesunate, Dihydroartemisinin-Piperaquine, and Pironaridine-Artesunate in Mozambique (PHASE4)
- Triple Artemisinin-based Combination Therapy for Delaying Drug Resistance Development - a Randomized Clinical Trial (PHASE2, PHASE3)
- Test Efficacy Study on the Recommended Antimalarial Drugs in the Democratic Republic of the Congo (PHASE4)
- Gametocytocidal and Transmission-blocking Efficacy of ASAQ and ALAQ With or Without PQ in Mali (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- amodiaquine+artesunate/artemether-lumefantrine CI brief — competitive landscape report
- amodiaquine+artesunate/artemether-lumefantrine updates RSS · CI watch RSS
- University of Ghana Medical School portfolio CI
Frequently asked questions about amodiaquine+artesunate/artemether-lumefantrine
What is amodiaquine+artesunate/artemether-lumefantrine?
How does amodiaquine+artesunate/artemether-lumefantrine work?
What is amodiaquine+artesunate/artemether-lumefantrine used for?
Who makes amodiaquine+artesunate/artemether-lumefantrine?
What drug class is amodiaquine+artesunate/artemether-lumefantrine in?
What development phase is amodiaquine+artesunate/artemether-lumefantrine in?
What are the side effects of amodiaquine+artesunate/artemether-lumefantrine?
What does amodiaquine+artesunate/artemether-lumefantrine target?
Related
- Drug class: All Antimalarial drugs
- Target: All drugs targeting Plasmodium heme detoxification pathway
- Manufacturer: University of Ghana Medical School — full pipeline
- Therapeutic area: All drugs in Infectious Diseases
- Indication: Drugs for Treatment of uncomplicated malaria
- Indication: Drugs for Treatment of severe malaria
- Compare: amodiaquine+artesunate/artemether-lumefantrine vs similar drugs
- Pricing: amodiaquine+artesunate/artemether-lumefantrine cost, discount & access