Allylamine antifungal

This page covers all Allylamine antifungal drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Squalene epoxidase, Lanosterol 14α-demethylase (CYP51), Sigma non-opioid intracellular receptor 1.

Targets

Squalene epoxidase · Lanosterol 14α-demethylase (CYP51) · Sigma non-opioid intracellular receptor 1

Marketed (5)

• NAFT500 (pediatric) · Merz North America, Inc. · Dermatology / Infectious Disease
  NAFT500 is a naftifine hydrochloride topical antifungal that inhibits fungal sterol synthesis by blocking squalene epoxidase.
• Loceryl NL 12 weeks · Galderma R&D · Dermatology / Infectious Disease
  Loceryl is a topical antifungal that inhibits fungal sterol synthesis by blocking lanosterol 14α-demethylase, disrupting the fungal cell membrane.
• Naftin · Legacy Pharma · Infectious Disease
  Naftin works by inhibiting the synthesis of ergosterol in fungal cell membranes.
• Lotrimin Ultra® · Sun Pharmaceutical Industries, Inc. · Dermatology / Infectious Disease
  Lotrimin Ultra contains butenafine, an allylamine antifungal that disrupts fungal cell membrane synthesis by inhibiting squalene epoxidase.
• Terbinafine Tablets · Oregon Health and Science University · Infectious Disease / Dermatology
  Terbinafine inhibits fungal squalene epoxidase, disrupting ergosterol synthesis and causing fungal cell membrane collapse.

Phase 3 pipeline (6)

• NAFT-600 ( naftin 2 % gel ) · Merz North America, Inc. · Dermatology
  Naftin is an allylamine antifungal that inhibits fungal sterol synthesis by blocking squalene epoxidase, disrupting the fungal cell membrane.
• terbinafine hydrogen chloride · Novartis · Infectious Disease / Dermatology
  Terbinafine inhibits fungal squalene epoxidase, blocking ergosterol synthesis and causing fungal cell membrane disruption and death.
• Naftifine Hydrochloride Cream 2% · Sun Pharmaceutical Industries, Inc. · Dermatology / Infectious Disease
  Naftifine is a fungistatic agent that inhibits fungal sterol synthesis by blocking squalene epoxidase, disrupting the fungal cell membrane.
• Butenafine HCl 1% (BAY1896425) · Bayer · Dermatology / Infectious Disease
  Butenafine HCl is an allylamine antifungal that disrupts fungal cell membrane integrity by inhibiting squalene epoxidase, leading to ergosterol depletion.
• Terbinafine Pill · Pak Emirates Military Hospital · Infectious Disease / Dermatology
  Terbinafine inhibits fungal squalene epoxidase, blocking ergosterol synthesis and causing fungal cell membrane disruption and death.
• Naftin 1% Cream · Merz North America, Inc. · Dermatology
  Naftin (naftifine) is a topical antifungal that inhibits fungal sterol synthesis by blocking squalene epoxidase, disrupting the fungal cell membrane.