Squalene epoxidase — Drug Target

All drugs that target Squalene epoxidase — marketed and clinical-stage. Includes 3 drug classes acting on this target.

Drug classes

Allylamine antifungal · Benzoxaborole antifungal · Topical antifungal (squalene epoxidase inhibitor)

Marketed (4)

• Lotrimin Ultra® · Sun Pharmaceutical Industries, Inc. · Allylamine antifungal · Dermatology / Infectious Disease
  Lotrimin Ultra contains butenafine, an allylamine antifungal that disrupts fungal cell membrane synthesis by inhibiting squalene epoxidase.
• Terbinafine Tablets · Oregon Health and Science University · Allylamine antifungal · Infectious Disease / Dermatology
  Terbinafine inhibits fungal squalene epoxidase, disrupting ergosterol synthesis and causing fungal cell membrane collapse.
• NAFT500 (pediatric) · Merz North America, Inc. · Allylamine antifungal · Dermatology / Infectious Disease
  NAFT500 is a naftifine hydrochloride topical antifungal that inhibits fungal sterol synthesis by blocking squalene epoxidase.
• Tavaborole 5% Topical Solution · Pfizer · Benzoxaborole antifungal · Dermatology/Infectious Disease
  Tavaborole inhibits fungal squalene epoxidase, disrupting ergosterol synthesis and causing fungal cell death.

Phase 3 pipeline (7)

• Naftifine Hydrochloride Cream 2% · Sun Pharmaceutical Industries, Inc. · Allylamine antifungal · Dermatology / Infectious Disease
  Naftifine is a fungistatic agent that inhibits fungal sterol synthesis by blocking squalene epoxidase, disrupting the fungal cell membrane.
• NAFT-600 ( naftin 2 % gel ) · Merz North America, Inc. · Allylamine antifungal · Dermatology
  Naftin is an allylamine antifungal that inhibits fungal sterol synthesis by blocking squalene epoxidase, disrupting the fungal cell membrane.
• Butenafine HCl 1% (BAY1896425) · Bayer · Allylamine antifungal · Dermatology / Infectious Disease
  Butenafine HCl is an allylamine antifungal that disrupts fungal cell membrane integrity by inhibiting squalene epoxidase, leading to ergosterol depletion.
• terbinafine hydrogen chloride · Novartis · Allylamine antifungal · Infectious Disease / Dermatology
  Terbinafine inhibits fungal squalene epoxidase, blocking ergosterol synthesis and causing fungal cell membrane disruption and death.
• Naftin 1% Cream · Merz North America, Inc. · Allylamine antifungal · Dermatology
  Naftin (naftifine) is a topical antifungal that inhibits fungal sterol synthesis by blocking squalene epoxidase, disrupting the fungal cell membrane.
• Terbinafine Pill · Pak Emirates Military Hospital · Allylamine antifungal · Infectious Disease / Dermatology
  Terbinafine inhibits fungal squalene epoxidase, blocking ergosterol synthesis and causing fungal cell membrane disruption and death.
• AN2690 Topical Solution, 5% · Pfizer · Topical antifungal (squalene epoxidase inhibitor) · Dermatology / Infectious Disease
  AN2690 is a topical antifungal that inhibits fungal squalene epoxidase, disrupting ergosterol synthesis in the fungal cell membrane.