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Terbinafine Pill
Terbinafine inhibits fungal squalene epoxidase, blocking ergosterol synthesis and causing fungal cell membrane disruption and death.
Terbinafine inhibits fungal squalene epoxidase, blocking ergosterol synthesis and causing fungal cell membrane disruption and death. Used for Onychomycosis (fungal nail infection), Tinea pedis (athlete's foot), Tinea corporis (ringworm).
At a glance
| Generic name | Terbinafine Pill |
|---|---|
| Also known as | Lamisil |
| Sponsor | Pak Emirates Military Hospital |
| Drug class | Allylamine antifungal |
| Target | Squalene epoxidase |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease / Dermatology |
| Phase | Phase 3 |
Mechanism of action
Terbinafine is a fungicidal agent that selectively inhibits the enzyme squalene epoxidase in the fungal sterol synthesis pathway. By blocking ergosterol production, an essential component of fungal cell membranes, the drug causes membrane instability and fungal cell death. It is particularly effective against dermatophytes and has broad antifungal activity.
Approved indications
- Onychomycosis (fungal nail infection)
- Tinea pedis (athlete's foot)
- Tinea corporis (ringworm)
- Tinea cruris (jock itch)
Common side effects
- Headache
- Diarrhea
- Rash
- Dyspepsia
- Taste disturbance
- Hepatotoxicity
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |