{"id":"terbinafine-pill","safety":{"commonSideEffects":[{"rate":"2-3%","effect":"Headache"},{"rate":"2-3%","effect":"Diarrhea"},{"rate":"1-2%","effect":"Rash"},{"rate":"1-2%","effect":"Dyspepsia"},{"rate":"0.5-1%","effect":"Taste disturbance"},{"rate":"0.1-0.3%","effect":"Hepatotoxicity"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"Terbinafine is a fungicidal agent that selectively inhibits the enzyme squalene epoxidase in the fungal sterol synthesis pathway. By blocking ergosterol production, an essential component of fungal cell membranes, the drug causes membrane instability and fungal cell death. It is particularly effective against dermatophytes and has broad antifungal activity.","oneSentence":"Terbinafine inhibits fungal squalene epoxidase, blocking ergosterol synthesis and causing fungal cell membrane disruption and death.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:38:10.912Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Onychomycosis (fungal nail infection)"},{"name":"Tinea pedis (athlete's foot)"},{"name":"Tinea corporis (ringworm)"},{"name":"Tinea cruris (jock itch)"}]},"trialDetails":[{"nctId":"NCT04880980","phase":"PHASE3","title":"Comparison of Efficacy of Double Dose Oral Terbinafine Vs Itraconazole in Treatment of Dermatophyte Infections of Skin.","status":"COMPLETED","sponsor":"Pak Emirates Military Hospital","startDate":"2021-03-15","conditions":"Dermatophyte Infection, Terbinafine Adverse Reaction, Itraconazole Adverse Reaction","enrollment":120}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Lamisil"],"phase":"phase_3","status":"active","brandName":"Terbinafine Pill","genericName":"Terbinafine Pill","companyName":"Pak Emirates Military Hospital","companyId":"pak-emirates-military-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Terbinafine inhibits fungal squalene epoxidase, blocking ergosterol synthesis and causing fungal cell membrane disruption and death. Used for Onychomycosis (fungal nail infection), Tinea pedis (athlete's foot), Tinea corporis (ringworm).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}