Acetylcholinesterase Inhibitor

This page covers all Acetylcholinesterase Inhibitor drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Beta-secretase 1, Multidrug resistance protein 1, Acetylcholine receptor subunit epsilon, Beta-adrenergic receptors; Acetylcholinesterase, Alpha-1 adrenergic receptor; acetylcholinesterase.

Targets

Beta-secretase 1, Multidrug resistance protein 1, Acetylcholine receptor subunit epsilon · Beta-adrenergic receptors; Acetylcholinesterase · Alpha-1 adrenergic receptor; acetylcholinesterase · Acetylcholinesterase · Acetylcholinesterase (neostigmine); muscarinic acetylcholine receptors (glycopyrrolate) · Acetylcholinesterase (neostigmine); Muscarinic acetylcholine receptors (glycopyrrolate) · Acetylcholinesterase; nicotinic acetylcholine receptors · Acetylcholinesterase (neostigmine); Muscarinic acetylcholine receptors (atropine) · Acetylcholinesterase (AChE) · Acetylcholinesterase; muscarinic acetylcholine receptors

Marketed (13)

• Donepezil (Aricept) · University of Virginia · Neuroscience
• Propranolol+pyridostigmine · Seoul National University Hospital · Neurology; Cardiovascular
  Propranolol blocks beta-adrenergic receptors to reduce heart rate and blood pressure, while pyridostigmine inhibits acetylcholinesterase to increase acetylcholine levels and enhance neuromuscular transmission.
• Midodrine + pyridostigmine · Seoul National University Hospital · Cardiovascular
  Midodrine and pyridostigmine together increase blood pressure and improve symptoms of orthostatic hypotension by enhancing sympathetic activation and acetylcholine availability.
• Huperzine A Injection · Second Affiliated Hospital of Wenzhou Medical University · Neurology
  Huperzine A inhibits acetylcholinesterase, increasing acetylcholine levels in the brain to improve cognitive function.
• Neostigmine w/ Glycopyrrolate · University of Texas Southwestern Medical Center · Neurology
  Neostigmine inhibits acetylcholinesterase to increase acetylcholine levels, while glycopyrrolate blocks muscarinic receptors to counteract cholinergic side effects.
• Neostigmine + Glycopyrrolate · Merck Sharp & Dohme LLC · Neuromuscular
  Neostigmine inhibits acetylcholinesterase to increase acetylcholine levels, while glycopyrrolate blocks muscarinic receptors to prevent cholinergic side effects.
• Galantamine (Reminyl) · Janssen-Cilag Pty Ltd · Neurology
  Galantamine inhibits acetylcholinesterase to increase acetylcholine levels in the brain, and also acts as an allosteric modulator of nicotinic receptors to enhance cholinergic neurotransmission.
• IV Neostigmine Methylsulfate + Atropine Sulphate · Damanhour Teaching Hospital · Neurology
  Neostigmine inhibits acetylcholinesterase to increase acetylcholine levels, while atropine blocks muscarinic receptors to prevent cholinergic toxicity.
• Donepezil HCI (drug) · Neurognostics · Neurology
  Donepezil inhibits acetylcholinesterase, increasing acetylcholine levels in the brain to improve cognitive function in Alzheimer's disease.
• TIVA - Neostigmine 70 · Pontificia Universidade Catolica de Sao Paulo · Neurology
  Neostigmine is a reversible acetylcholinesterase inhibitor that increases acetylcholine levels at the neuromuscular junction and in the central nervous system.
• Neostigmine with glycopyrrolate · The Cleveland Clinic · Neurology
  Neostigmine inhibits acetylcholinesterase to increase acetylcholine levels, while glycopyrrolate blocks muscarinic receptors to counteract cholinergic side effects.
• Placebo/Galantamine (Reminyl®) · Ludwig-Maximilians - University of Munich · Neurology
  Galantamine inhibits acetylcholinesterase to increase acetylcholine levels in the brain, improving cognitive function in Alzheimer's disease.
• Neostigmine+Glycopyrronium · Pusan National University Yangsan Hospital · Neurology
  Neostigmine inhibits acetylcholinesterase to increase acetylcholine levels, while glycopyrronium blocks muscarinic receptors to counteract cholinergic side effects.

Phase 3 pipeline (4)

• Donepezil drug treatment · Shanghai Jiao Tong University School of Medicine · Neurology
  Donepezil inhibits acetylcholinesterase, increasing acetylcholine levels in the brain to improve cognitive function in Alzheimer's disease.
• Aricept (donepezil IR 10 mg) · Eisai Inc. · Neurology
  Donepezil inhibits acetylcholinesterase, increasing acetylcholine levels in the brain to improve cognitive function in Alzheimer's disease.
• Aricept (donepezil SR 23 mg) · Eisai Inc. · Neurology
  Donepezil is an acetylcholinesterase inhibitor that increases acetylcholine levels in the brain by blocking the enzyme that breaks it down.
• Octohydroaminoacridine Succinate · Shanghai Mental Health Center · Neurology
  Octohydroaminoacridine succinate is a cognitive enhancer that likely increases acetylcholine levels in the brain by inhibiting acetylcholinesterase.

Patent intelligence

• acetylcholinesterase inhibitor patent landscape — aggregated cliff calendar, attackable patents, originator estates