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IV Neostigmine Methylsulfate + Atropine Sulphate
IV Neostigmine Methylsulfate + Atropine Sulphate is a Acetylcholinesterase inhibitor + Antimuscarinic Small molecule drug developed by Damanhour Teaching Hospital. It is currently FDA-approved for Myasthenia gravis, Reversal of neuromuscular blockade, Postoperative ileus. Also known as: Neostigmine ampoule, Atropine ampoule.
Neostigmine inhibits acetylcholinesterase to increase acetylcholine levels, while atropine blocks muscarinic receptors to prevent cholinergic toxicity.
Neostigmine inhibits acetylcholinesterase to increase acetylcholine levels, while atropine blocks muscarinic receptors to prevent cholinergic toxicity. Used for Myasthenia gravis, Reversal of neuromuscular blockade, Postoperative ileus.
At a glance
| Generic name | IV Neostigmine Methylsulfate + Atropine Sulphate |
|---|---|
| Also known as | Neostigmine ampoule, Atropine ampoule |
| Sponsor | Damanhour Teaching Hospital |
| Drug class | Acetylcholinesterase inhibitor + Antimuscarinic |
| Target | Acetylcholinesterase (neostigmine); Muscarinic acetylcholine receptors (atropine) |
| Modality | Small molecule |
| Therapeutic area | Neurology |
| Phase | FDA-approved |
Mechanism of action
Neostigmine methylsulfate is a reversible acetylcholinesterase inhibitor that increases acetylcholine concentration at the neuromuscular junction and autonomic sites. Atropine sulphate is a muscarinic antagonist co-administered to block the unwanted parasympathomimetic effects (salivation, bronchospasm, bradycardia) of excess acetylcholine while preserving the beneficial nicotinic effects at the neuromuscular junction.
Approved indications
- Myasthenia gravis
- Reversal of neuromuscular blockade
- Postoperative ileus
- Urinary retention
Common side effects
- Muscle fasciculations
- Increased salivation (despite atropine)
- Bronchospasm
- Bradycardia
- Nausea and vomiting
- Abdominal cramping
Key clinical trials
- Impact of Sugammadex Versus Neostigmine on Early Postoperative Pulmonary Function (NA)
- A Comparative Study Between Combination of Propofol and Dexmedetomidine Versus Propofol Alone in Anesthesia for Rigid Bronchoscopy by Using the Patient State Index Monitor (PHASE4)
- Efficacy, Safety, and Pharmacokinetics of Sugammadex (MK-8616) for Reversal of Neuromuscular Blockade in Pediatric Participants Aged Birth to <2 Years (MK-8616-169) (PHASE4)
- Effects Of Anaesthesia on Intraocular Pressure in Robotic Prostate Surgery (NA)
- Open and Laparoscopic Total Extraperitoneal Repair Under Spinal Anesthesia Versus General Anesthesia (NA)
- Effects of Sugammadex and Conventional Reversal on Lung Function in Laparoscopic Abdominal Surgery (NA)
- Direct Versus US Guided PECS Block on Controlling Postmastectomy Pain (NA)
- Axillary Brachial Plexus Block Using 0.25% Bupivacaine Versus Using 0.19%Bupivacaine in Pediatrics (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- IV Neostigmine Methylsulfate + Atropine Sulphate CI brief — competitive landscape report
- IV Neostigmine Methylsulfate + Atropine Sulphate updates RSS · CI watch RSS
- Damanhour Teaching Hospital portfolio CI
Frequently asked questions about IV Neostigmine Methylsulfate + Atropine Sulphate
What is IV Neostigmine Methylsulfate + Atropine Sulphate?
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Related
- Drug class: All Acetylcholinesterase inhibitor + Antimuscarinic drugs
- Target: All drugs targeting Acetylcholinesterase (neostigmine); Muscarinic acetylcholine receptors (atropine)
- Manufacturer: Damanhour Teaching Hospital — full pipeline
- Therapeutic area: All drugs in Neurology
- Indication: Drugs for Myasthenia gravis
- Indication: Drugs for Reversal of neuromuscular blockade
- Indication: Drugs for Postoperative ileus
- Also known as: Neostigmine ampoule, Atropine ampoule
- Compare: IV Neostigmine Methylsulfate + Atropine Sulphate vs similar drugs
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