Effects of Sugammadex and Conventional Reversal on Lung Function in Laparoscopic Abdominal Surgery

NCT06210165 NA UNKNOWN

The goal of this clincal trial is to determine the differences in few parameter of lung function (ie Forced Vital Capacity (FCV)) between Sugammadex and conventional reversal in laparoscopic abdominal surgery. The main questions it aims to answer are: 1. Is there differences in the pulmonary function test preoperative and post extubation between Sugammadex and conventional reversal in laparoscopic abdominal surgery? 2. Is there differences in the size of atelectasis area between Sugammadex and conventional reversal in laparoscopic abdominal surgery? 3. Is there differences between sugammadex and conventional reversal in postoperative mean length of stay in laparoscopic abdominal surgery? Participants will be asked 1. to do baseline spirometry before operation 2. to be examined for lung ultrasound before operation 3. to be given either sugammadex or neostigmine as reversal after operation is completed 4. to repeat spirometry after operation for few times 5. to be examined for lung ultrasound after operation Researcher will compare sugammadex group and conventional group to see if any difference in term of lung function, size of atelectasis and length of stay.

Details

Lead sponsor	Rhendra Hardy Mohamad Zaini
Phase	NA
Status	UNKNOWN
Enrolment	80
Start date	2022-12-07
Completion	2024-06

Conditions

• Atelectasis, Postoperative
• Pulmonary Function; Newborn, Abnormal

Interventions

• Sugammadex
• Neostigmine and atropine

Primary outcomes

• Lung Function — Preoperative (Hour 1)to 24H post extubation (Hour 24)
  compare the Forced Vital Capacity (FVC), Forced Expiratory Volume in the first second (FEV1), and FEV1/FVC using portable spirometry preoperative and post extubation between sugammadex and conventional reversal in laparoscopic abdominal surgery

Countries

Malaysia