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Malathion Shampoo 0.5%
Malathion is an organophosphate insecticide that inhibits acetylcholinesterase in parasitic arthropods, causing paralysis and death.
Malathion is an organophosphate insecticide that inhibits acetylcholinesterase in parasitic arthropods, causing paralysis and death. Used for Head lice infestation (Pediculus humanus capitis), Body lice infestation (Pediculus humanus humanus), Pubic lice infestation (Phthirus pubis).
At a glance
| Generic name | Malathion Shampoo 0.5% |
|---|---|
| Sponsor | London School of Hygiene and Tropical Medicine |
| Drug class | Organophosphate insecticide |
| Target | Acetylcholinesterase |
| Modality | Small molecule |
| Therapeutic area | Parasitology / Dermatology |
| Phase | Phase 3 |
Mechanism of action
Malathion irreversibly phosphorylates acetylcholinesterase at the neuromuscular junction of lice and other parasitic arthropods, preventing breakdown of acetylcholine and leading to excessive cholinergic stimulation, paralysis, and death of the parasite. The shampoo formulation allows topical application directly to affected areas of the scalp and hair.
Approved indications
- Head lice infestation (Pediculus humanus capitis)
- Body lice infestation (Pediculus humanus humanus)
- Pubic lice infestation (Phthirus pubis)
Common side effects
- Scalp irritation
- Pruritus
- Erythema
- Contact dermatitis
- Hair discoloration
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |