{"id":"malathion-shampoo-0-5","safety":{"commonSideEffects":[{"rate":null,"effect":"Scalp irritation"},{"rate":null,"effect":"Pruritus"},{"rate":null,"effect":"Erythema"},{"rate":null,"effect":"Contact dermatitis"},{"rate":null,"effect":"Hair discoloration"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Malathion irreversibly phosphorylates acetylcholinesterase at the neuromuscular junction of lice and other parasitic arthropods, preventing breakdown of acetylcholine and leading to excessive cholinergic stimulation, paralysis, and death of the parasite. The shampoo formulation allows topical application directly to affected areas of the scalp and hair.","oneSentence":"Malathion is an organophosphate insecticide that inhibits acetylcholinesterase in parasitic arthropods, causing paralysis and death.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:20:06.149Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Head lice infestation (Pediculus humanus capitis)"},{"name":"Body lice infestation (Pediculus humanus humanus)"},{"name":"Pubic lice infestation (Phthirus pubis)"}]},"trialDetails":[{"nctId":"NCT03236168","phase":"PHASE3","title":"Impact of Community Scabies Treatment on Head Lice Prevalence in the Solomon Islands","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2017-08-01","conditions":"Scabies, Head Lice","enrollment":118}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":6,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Malathion Shampoo 0.5%","genericName":"Malathion Shampoo 0.5%","companyName":"London School of Hygiene and Tropical Medicine","companyId":"london-school-of-hygiene-and-tropical-medicine","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Malathion is an organophosphate insecticide that inhibits acetylcholinesterase in parasitic arthropods, causing paralysis and death. Used for Head lice infestation (Pediculus humanus capitis), Body lice infestation (Pediculus humanus humanus), Pubic lice infestation (Phthirus pubis).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}