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Ifosphamide, Etoposide, Methotrexate, Vindelsine, Prednisone
Ifosphamide, Etoposide, Methotrexate, Vindelsine, Prednisone is a Alkylating agent Small molecule drug developed by Children's Cancer Group, China. It is currently in Phase 2 development for Acute lymphoblastic leukemia, Breast cancer, Lymphoma. Also known as: Protocol BB.
Topoisomerase inhibitor
Topoisomerase inhibitor Used for Acute lymphoblastic leukemia, Breast cancer, Lymphoma.
At a glance
| Generic name | Ifosphamide, Etoposide, Methotrexate, Vindelsine, Prednisone |
|---|---|
| Also known as | Protocol BB |
| Sponsor | Children's Cancer Group, China |
| Drug class | Alkylating agent |
| Target | Topoisomerase II |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | Phase 2 |
Mechanism of action
Ifosphamide is a topoisomerase II inhibitor that works by interfering with the enzyme topoisomerase II, which is involved in DNA replication and transcription. This leads to DNA damage and ultimately cell death.
Approved indications
- Acute lymphoblastic leukemia
- Breast cancer
- Lymphoma
- Ovarian cancer
- Testicular cancer
Common side effects
- Myelosuppression
- Nausea and vomiting
- Hair loss
- Diarrhea
- Stomatitis
Key clinical trials
- BNHL-2015 for Children or Adolescents in China (PHASE2, PHASE3)
- Chemotherapy With Rituximab for Aggressive B-NHL in Children and Adolescents (PHASE2, PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Ifosphamide, Etoposide, Methotrexate, Vindelsine, Prednisone CI brief — competitive landscape report
- Ifosphamide, Etoposide, Methotrexate, Vindelsine, Prednisone updates RSS · CI watch RSS
- Children's Cancer Group, China portfolio CI
Frequently asked questions about Ifosphamide, Etoposide, Methotrexate, Vindelsine, Prednisone
What is Ifosphamide, Etoposide, Methotrexate, Vindelsine, Prednisone?
How does Ifosphamide, Etoposide, Methotrexate, Vindelsine, Prednisone work?
What is Ifosphamide, Etoposide, Methotrexate, Vindelsine, Prednisone used for?
Who makes Ifosphamide, Etoposide, Methotrexate, Vindelsine, Prednisone?
Is Ifosphamide, Etoposide, Methotrexate, Vindelsine, Prednisone also known as anything else?
What drug class is Ifosphamide, Etoposide, Methotrexate, Vindelsine, Prednisone in?
What development phase is Ifosphamide, Etoposide, Methotrexate, Vindelsine, Prednisone in?
What are the side effects of Ifosphamide, Etoposide, Methotrexate, Vindelsine, Prednisone?
What does Ifosphamide, Etoposide, Methotrexate, Vindelsine, Prednisone target?
Related
- Drug class: All Alkylating agent drugs
- Target: All drugs targeting Topoisomerase II
- Manufacturer: Children's Cancer Group, China — full pipeline
- Therapeutic area: All drugs in Oncology
- Indication: Drugs for Acute lymphoblastic leukemia
- Indication: Drugs for Breast cancer
- Indication: Drugs for Lymphoma
- Also known as: Protocol BB
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