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Oxaliplatin(Aiheng)
Oxaliplatin(Aiheng) is a Platinum-based chemotherapy Small molecule drug developed by The First Affiliated Hospital of Henan University of Science and Technology. It is currently in Phase 3 development for Metastatic colorectal cancer, Adjuvant treatment of stage III colon cancer. Also known as: Aiheng.
Oxaliplatin works by interfering with DNA replication in cancer cells, leading to cell death.
Oxaliplatin works by interfering with DNA replication in cancer cells, leading to cell death. Used for Metastatic colorectal cancer, Adjuvant treatment of stage III colon cancer.
At a glance
| Generic name | Oxaliplatin(Aiheng) |
|---|---|
| Also known as | Aiheng |
| Sponsor | The First Affiliated Hospital of Henan University of Science and Technology |
| Drug class | Platinum-based chemotherapy |
| Target | DNA |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | Phase 3 |
Mechanism of action
Oxaliplatin is a platinum-based chemotherapy drug that forms platinum-DNA adducts, which prevent DNA replication and transcription, ultimately causing cell death in rapidly dividing cancer cells. This mechanism is particularly effective against colorectal cancer cells.
Approved indications
- Metastatic colorectal cancer
- Adjuvant treatment of stage III colon cancer
Common side effects
- Neurotoxicity
- Myelosuppression
- Diarrhea
- Nausea and vomiting
- Fatigue
Key clinical trials
- Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial (PHASE2)
- Testing the Addition of an Immunotherapy Agent, Atezolizumab, When Given With the Usual Chemo-Immunotherapy Drug Combination (Rituximab Plus Gemcitabine and Oxaliplatin) for Relapsed/Refractory (That Has Come Back or Not Responded to Treatment) Transformed Diffuse Large B-Cell Lymphoma (PHASE1)
- Testing the Addition of Atezolizumab to Combination Chemotherapy or Atezolizumab Alone for Metastatic Colon or Rectal Cancer, the COMMIT Study (PHASE3)
- Study of Chemotherapy, With or Without Binimetinib in Advanced Biliary Tract Cancers in 2nd Line Setting (A ComboMATCH Treatment Trial) (PHASE2)
- Clinical Trial of an Anti-cancer Drug, CA-4948 (Emavusertib), in Combination With Chemotherapy Treatment (FOLFOX Plus Bevacizumab) in Metastatic Colorectal Cancer (PHASE1)
- Oxaliplatin, Leucovorin, and Fluorouracil With or Without Bevacizumab in Treating Patients Who Have Undergone Surgery for Stage II Colon Cancer (PHASE3)
- Testing Pump Chemotherapy in Addition to Standard of Care Chemotherapy Versus Standard of Care Chemotherapy Alone for Patients With Unresectable Colorectal Liver Metastases: The PUMP Trial (PHASE3)
- Testing the Addition of Radiotherapy to the Usual Treatment (Chemotherapy) for Patients With Esophageal and Gastric Cancer That Has Spread to a Limited Number of Other Places in the Body (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Oxaliplatin(Aiheng) CI brief — competitive landscape report
- Oxaliplatin(Aiheng) updates RSS · CI watch RSS
- The First Affiliated Hospital of Henan University of Science and Technology portfolio CI
Frequently asked questions about Oxaliplatin(Aiheng)
What is Oxaliplatin(Aiheng)?
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Is Oxaliplatin(Aiheng) also known as anything else?
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Related
- Drug class: All Platinum-based chemotherapy drugs
- Target: All drugs targeting DNA
- Manufacturer: The First Affiliated Hospital of Henan University of Science and Technology — full pipeline
- Therapeutic area: All drugs in Oncology
- Indication: Drugs for Metastatic colorectal cancer
- Indication: Drugs for Adjuvant treatment of stage III colon cancer
- Also known as: Aiheng