COX-1 and COX-2 — Drug Target
All drugs that target COX-1 and COX-2 — marketed and clinical-stage. Includes 7 drug classes acting on this target.
Drug classes
Nonsteroidal anti-inflammatory drug (NSAID) · NSAID (nonsteroidal anti-inflammatory drug) · Non-selective NSAID · Non-steroidal anti-inflammatory drug (NSAID) · NSAID and muscle relaxant · NSAID · Topical NSAID
Marketed (15)
- ABS · Teva Branded Pharmaceutical Products R&D, Inc. · Nonsteroidal anti-inflammatory drug (NSAID) · Cardiovascular
Acetylsalicylic acid acts as a non-selective COX inhibitor, reducing inflammation and platelet aggregation. - High Dose Ibuprofen · Ottawa Hospital Research Institute · Nonsteroidal anti-inflammatory drug (NSAID) · Pain Management, Inflammation, Rheumatology
High-dose ibuprofen inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation, pain, and fever. - ACULAR · University of South Alabama · NSAID (nonsteroidal anti-inflammatory drug) · Ophthalmology
Acular (ketorolac tromethamine) is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis and thereby decrease inflammation and pain. - DICL-SR · Kunming Baker Norton Pharmaceutical Sales Co., Ltd. · NSAID (nonsteroidal anti-inflammatory drug) · Rheumatology / Pain Management
DICL-SR is a sustained-release formulation of diclofenac that inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis and provide anti-inflammatory, analgesic, and antipyretic effects. - Ibuprofen (Advil) · Bayer · Nonsteroidal anti-inflammatory drug (NSAID) · Pain Management, Inflammation
Ibuprofen inhibits cyclooxygenase (COX) enzymes to reduce the production of prostaglandins, thereby decreasing inflammation, pain, and fever. - Non-selective NSAIDS · Pfizer's Upjohn has merged with Mylan to form Viatris Inc. · Non-selective NSAID · Pain Management, Rheumatology, Cardiovascular
Non-selective NSAIDs inhibit both COX-1 and COX-2 enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation, pain, and fever. - Ketoprofen Lysine Salt · Dompé Farmaceutici S.p.A · Nonsteroidal anti-inflammatory drug (NSAID) · Pain Management / Rheumatology
Ketoprofen lysine salt is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis and provide analgesic, anti-inflammatory, and antipyretic effects. - Diclofenac oral + Placebo Oral · Hospital de Clinicas de Porto Alegre · Nonsteroidal anti-inflammatory drug (NSAID) · Pain Management / Rheumatology
Diclofenac inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation and pain. - Indomethacin suppository · Azienda USL Reggio Emilia - IRCCS · Nonsteroidal anti-inflammatory drug (NSAID) · Pain management, Rheumatology, Gastroenterology
Indomethacin inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation, pain, and fever. - NSAID (Ketorolac/Ibuprofen) · Thomas Jefferson University · Non-steroidal anti-inflammatory drug (NSAID) · Pain Management, Inflammation
NSAIDs inhibit cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation, pain, and fever. - Ibuprofen Acid · Reckitt Benckiser Healthcare (UK) Limited · Nonsteroidal anti-inflammatory drug (NSAID) · Pain Management, Inflammation
Ibuprofen inhibits cyclooxygenase (COX) enzymes to reduce the production of prostaglandins, thereby decreasing inflammation, pain, and fever. - Ibuprofen Tablets · Overseas Pharmaceuticals, Ltd. · Nonsteroidal anti-inflammatory drug (NSAID) · Pain Management, Inflammation, Rheumatology
Ibuprofen inhibits cyclooxygenase (COX) enzymes to reduce the production of prostaglandins, thereby decreasing inflammation, pain, and fever. - Topical Diclofenac gel 1% · University of California, Davis · Nonsteroidal anti-inflammatory drug (NSAID) · Rheumatology / Pain Management
Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation and pain at the site of application. - Intravenous ibuprofen · Biomendi S.A.U. · Nonsteroidal anti-inflammatory drug (NSAID) · Pain Management, Inflammation
Intravenous ibuprofen inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation and pain. - Diclofenac 1% · Daré Bioscience, Inc. · Nonsteroidal anti-inflammatory drug (NSAID) · Pain Management / Rheumatology
Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation and pain.
Phase 3 pipeline (17)
- ketoprofen and cyclobenzaprine association · EMS · NSAID and muscle relaxant · Pain management
Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase enzymes, reducing prostaglandin synthesis and inflammation, while cyclobenzaprine is a muscle relaxant that acts as a central nervous system depressant, affecting the brain's motor control centers. - ketorolac eye drops · Allergan · NSAID · Ophthalmology
Ketorolac eye drops work by reducing inflammation and pain in the eye by inhibiting prostaglandin synthesis. - Ketorolac Oral Tablet [Toradol] · Montefiore Medical Center · Nonsteroidal anti-inflammatory drug (NSAID) · Pain Management
Ketorolac inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation and pain. - Topical IBU three times daily · Pfizer · NSAID · Pain management
Topical IBU works by reducing pain and inflammation at the site of application. - ketoprofen in Diractin® · IDEA AG · NSAID · Pain management, Inflammation
Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation and pain. - Standard ibuprofen treatment · Fundacion para la Investigacion Biomedica del Hospital Universitario la Paz · Nonsteroidal anti-inflammatory drug (NSAID) · Pain management, Inflammation
Ibuprofen works by inhibiting the enzyme cyclooxygenase (COX), which is involved in the production of prostaglandins, leading to a reduction in inflammation and pain. - AMZ001 Diclofenac gel · Amzell · Nonsteroidal anti-inflammatory drug (NSAID) · Pain Management / Rheumatology
Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation and pain. - Naproxen sodium ER (BAYH6689) · Bayer · Nonsteroidal anti-inflammatory drug (NSAID) · Pain Management / Rheumatology
Naproxen sodium ER is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation and pain. - Placebo to ibuprofen · Organon and Co · NSAID · Pain management, Inflammation
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the enzyme cyclooxygenase (COX), which is responsible for producing prostaglandins that cause pain and inflammation. - Diclofenac Test (lower dose) · Iroko Pharmaceuticals, LLC · Nonsteroidal anti-inflammatory drug (NSAID) · Pain Management / Rheumatology
Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis and decrease inflammation and pain. - Novel Ibuprofen · Pfizer · Nonsteroidal anti-inflammatory drug (NSAID) · Pain Management / Inflammation
Novel Ibuprofen inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis and decrease inflammation, pain, and fever. - aspirin placebo (ASA Pbo) · Abbott · Nonsteroidal anti-inflammatory drug (NSAID) · Cardiovascular
Aspirin works by inhibiting the enzyme cyclooxygenase (COX), which is involved in the production of prostaglandins and thromboxanes. - Diclofenac Test (upper dose) · Iroko Pharmaceuticals, LLC · Nonsteroidal anti-inflammatory drug (NSAID) · Pain Management / Rheumatology
Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis and decrease inflammation and pain. - Intranasal Diclofenac Sodium · Bezmialem Vakif University · Nonsteroidal anti-inflammatory drug (NSAID) · Pain Management
Intranasal diclofenac sodium is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation and pain. - Intravenous lornoxicam · Diskapi Teaching and Research Hospital · Nonsteroidal anti-inflammatory drug (NSAID) · Pain Management, Rheumatology
Lornoxicam is a non-selective nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis and provide analgesic, anti-inflammatory, and antipyretic effects. - PENNSAID Gel · Mallinckrodt · Topical NSAID · Rheumatology / Pain Management
PENNSAID is a topical nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis and inflammation at the site of application. - IBU BID · Pfizer · NSAID (nonsteroidal anti-inflammatory drug) · Pain Management / Rheumatology
IBU BID is ibuprofen formulated for twice-daily dosing to provide sustained anti-inflammatory and analgesic effects.
Phase 2 pipeline (1)
- Indomethacin Capsules high dose · Iroko Pharmaceuticals, LLC · NSAID · Rheumatology
Non-selective COX-1 and COX-2 inhibitor
Phase 1 pipeline (2)
- Acetylsalicylzuur Apotex Cardio · AstraZeneca · NSAID · Cardiovascular
Inhibits COX-1 and COX-2 enzymes - Aspirin Aspro · Bayer · Nonsteroidal anti-inflammatory drug (NSAID) · Oncology, Cardiovascular, Neurology
Inhibits COX-1 and COX-2 enzymes