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High Dose Ibuprofen
High-dose ibuprofen inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation, pain, and fever.
High-dose ibuprofen inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation, pain, and fever. Used for Rheumatoid arthritis, Osteoarthritis, Acute pain and inflammation.
At a glance
| Generic name | High Dose Ibuprofen |
|---|---|
| Sponsor | Ottawa Hospital Research Institute |
| Drug class | Nonsteroidal anti-inflammatory drug (NSAID) |
| Target | COX-1 and COX-2 |
| Modality | Small molecule |
| Therapeutic area | Pain Management, Inflammation, Rheumatology |
| Phase | FDA-approved |
Mechanism of action
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that non-selectively inhibits COX-1 and COX-2 enzymes. By blocking these enzymes, it reduces the production of prostaglandins, which are key mediators of inflammation, pain, and fever. At higher doses, the anti-inflammatory effects are more pronounced than at standard doses.
Approved indications
- Rheumatoid arthritis
- Osteoarthritis
- Acute pain and inflammation
- Fever
Common side effects
- Gastrointestinal bleeding or ulceration
- Dyspepsia
- Nausea
- Renal impairment
- Cardiovascular events (at high doses/prolonged use)
- Headache
Key clinical trials
- Postoperative Analgesic Efficacy of SPSIPB in Anterior Cervical Discectomy (NA)
- Interscalene Block vs Serratus Posterior Superior Intercostal Plane Block (NA)
- Ultrasound-Guided Regional Blocks for Postoperative Analgesia After Laparoscopic Cholecystectomy (NA)
- Modified Thoracoabdominal Nerve Plane Block In Laparoscopic Sleeve Gastrectomy (NA)
- Recto-Intercostal Fascial Plane (RIFP) Block in Laparoscopic Cholecystectomy Patients (NA)
- RCT: Suzetrigine vs Norco for Post-op Pain (PHASE4)
- SPSIPB vs SAPB for Thoracoscopic Surgery (NA)
- Muscle Relaxation for Pediatric Adenotonsillectomy (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- High Dose Ibuprofen CI brief — competitive landscape report
- High Dose Ibuprofen updates RSS · CI watch RSS
- Ottawa Hospital Research Institute portfolio CI