NSAID

This page covers all NSAID drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting COX enzymes, Aldo-keto reductase family 1 member C2, Aldo-keto reductase family 1 member C3, Prostaglandin G/H synthase 1, COX-1 and COX-2.

Targets

COX enzymes · Aldo-keto reductase family 1 member C2, Aldo-keto reductase family 1 member C3, Prostaglandin G/H synthase 1 · COX-1 and COX-2 · COX · COX-2 · COX-1, COX-2

Marketed (2)

• quadratus without triamcinolone. · Hospital de Braga · Pain management
  Quadratus is a medication that works by inhibiting the activity of certain enzymes in the body.
• Aleve · Generic (originally Syntex) · Immunology
  Reversibly inhibits COX-1 and COX-2 with a long half-life, providing sustained anti-inflammatory, analgesic, and antipyretic effects.

Phase 3 pipeline (19)

• Topical IBU three times daily · Pfizer · Pain management
  Topical IBU works by reducing pain and inflammation at the site of application.
• aspirin continuation · Seoul National University Hospital · Cardiovascular
  Aspirin continuation works by inhibiting the enzyme cyclooxygenase, which is involved in the production of prostaglandins and thromboxanes, leading to a decrease in platelet aggregation and blood clot formation.
• SST-0225 Topical Ibuprofen Cream · Strategic Science & Technologies, LLC · Pain Management
  SST-0225 Topical Ibuprofen Cream works by reducing inflammation and relieving pain through the topical application of ibuprofen.
• Topical IBU twice daily · Pfizer · Pain Management
  Topical IBU works by reducing pain and inflammation at the site of application.
• benzydamine HCl · Prince of Songkla University · Pain management
  Benzydamine HCl is a nonsteroidal anti-inflammatory drug (NSAID) that acts as a cyclooxygenase (COX) inhibitor.
• diclofenac diethylamine, DDEA 2.32% gel · Novartis · Rheumatology
  Diclofenac diethylamine works by inhibiting the enzyme cyclooxygenase (COX), which is involved in the production of prostaglandins, leading to a reduction in inflammation and pain.
• Naproxen(drug) · Chinese University of Hong Kong · Rheumatology, Pain Management
  Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits the enzyme cyclooxygenase (COX), leading to a reduction in prostaglandin synthesis and subsequent inflammation.
• Test naproxen sodium tablet · Johnson & Johnson Consumer Inc., McNeil Consumer Healthcare Division · Pain management, Inflammation
  Naproxen sodium is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the enzyme cyclooxygenase (COX), which is responsible for producing prostaglandins that cause pain and inflammation.
• Placebo to etoricoxib · Organon and Co · Rheumatology
  Etoricoxib is a nonsteroidal anti-inflammatory drug (NSAID) that selectively inhibits COX-2, reducing prostaglandin synthesis and inflammation.
• topical intraoral ketoprofen gel · Behar, Caren, M.D. · Oral Health
  Topical intraoral ketoprofen gel works by reducing inflammation and pain in the mouth through the action of ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID).
• Toragesic® · Apsen Farmaceutica S.A. · Pain management
  Toragesic is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting prostaglandin synthesis.
• Vehicle Diclofenac Sodium Topical Gel · Amneal Pharmaceuticals, LLC · Pain Management
  Diclofenac sodium works by inhibiting the enzyme cyclooxygenase (COX), which is involved in the production of prostaglandins, leading to reduced inflammation and pain.
• Topical, intra-oral ketoprofen gel · Behar, Caren, M.D. · Pain management
  Ketoprofen works by inhibiting the enzyme cyclooxygenase (COX), which is involved in the production of prostaglandins, leading to reduced inflammation and pain.
• ketoprofen in Diractin® · IDEA AG · Pain management, Inflammation
  Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation and pain.
• Voltaren Topical Gel, 1% · Amneal Pharmaceuticals, LLC · Musculoskeletal
  Voltaren Topical Gel, 1% works by reducing inflammation and pain through the inhibition of prostaglandin synthesis.
• Placebo to ibuprofen · Organon and Co · Pain management, Inflammation
  Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the enzyme cyclooxygenase (COX), which is responsible for producing prostaglandins that cause pain and inflammation.
• acetaminophen plus ibuprofen · Nova Scotia Health Authority · Pain management
  Acetaminophen works by inhibiting the production of prostaglandins, which are chemicals that cause pain and fever, while ibuprofen works by inhibiting the enzyme COX-2, which is involved in the production of prostaglandins.
• saline infusion, ketoprofen, paracetamol · American University of Beirut Medical Center · Pain management
  Saline infusion is a solution of salt and water used to replenish fluids, ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces pain and inflammation, and paracetamol is an analgesic and antipyretic that reduces pain and fever.
• ketorolac eye drops · Allergan · Ophthalmology
  Ketorolac eye drops work by reducing inflammation and pain in the eye by inhibiting prostaglandin synthesis.

Phase 2 pipeline (11)

• ATB-346 low dose · Antibe Therapeutics Inc. · Pain
  ATB-346 low dose is a nonsteroidal anti-inflammatory drug (NSAID) that selectively targets COX-2 to reduce gastrointestinal toxicity.
• Ibuvix® - ibuprofen · Apsen Farmaceutica S.A. · Oncology
  Inhibits COX-2 enzyme
• Ketoprofen in Transfersome · IDEA AG · Pain Management
  Inhibits COX-2
• Diclofenac Capsules high dose · Iroko Pharmaceuticals, LLC · Rheumatology
  Diclofenac works by inhibiting the enzyme cyclooxygenase (COX), which is involved in the production of prostaglandins, leading to reduced inflammation and pain.
• Indomethacin Capsules high dose · Iroko Pharmaceuticals, LLC · Rheumatology
  Non-selective COX-1 and COX-2 inhibitor
• Diclofenac Capsules low dose · Iroko Pharmaceuticals, LLC · Rheumatology
  Diclofenac works by inhibiting the enzyme cyclooxygenase (COX), which is involved in the production of prostaglandins, leading to reduced inflammation and pain.
• Diclofenac Sodium Active Topical Patch 2 · Noven Pharmaceuticals, Inc. · Pain Management
  Diclofenac Sodium is a non-selective COX-2 inhibitor.
• ATB-346 standard dose · Antibe Therapeutics Inc. · Pain
  ATB-346 is a nonsteroidal anti-inflammatory drug (NSAID) that selectively targets COX-2 to reduce gastrointestinal toxicity.
• Intravenous Ketorolac Tromethamine · Oman Medical Speciality Board · Pain Management
  Intravenous Ketorolac Tromethamine is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the enzyme cyclooxygenase (COX), which is involved in the production of prostaglandins, leading to reduced inflammation and pain.
• Diclofenac Sodium Active Topical Patch 1 · Noven Pharmaceuticals, Inc. · Pain Management
  Diclofenac Sodium is a non-selective COX-2 inhibitor.
• ATB-346 mid-dose · Antibe Therapeutics Inc. · Pain
  ATB-346 mid-dose is a nonsteroidal anti-inflammatory drug (NSAID) that selectively targets COX-2 to reduce gastrointestinal toxicity.

Phase 1 pipeline (3)

• Acetylsalicylzuur Apotex Cardio · AstraZeneca · Cardiovascular
  Inhibits COX-1 and COX-2 enzymes
• Advil PM Liqui-Gels Minis · HALEON · Pain Management
  Acetaminophen is a non-selective COX inhibitor.
• Advil PM Liqui-Gels · HALEON · Pain Management
  Ibuprofen is a non-selective COX-2 inhibitor.