COX-2 — Drug Target

All drugs that target COX-2 — marketed and clinical-stage. Includes 10 drug classes acting on this target.

Drug classes

Nonsteroidal anti-inflammatory drug (NSAID) · Non-steroidal anti-inflammatory · Nonsteroidal Anti-inflammatory Drug [EPC] · Non-steroidal anti-inflammatory drug (NSAID) · NSAID · COX-2 inhibitor · Selective enzyme inhibitor · small molecule · Non-opioid analgesic · Anti-inflammatory

Marketed (4)

• Nerkardou (5 mg) & (10 mg) · Genuine Research Center, Egypt · Nonsteroidal anti-inflammatory drug (NSAID) · Rheumatology
  Nerkardou is an anti-inflammatory agent that works by inhibiting the production of pro-inflammatory cytokines.
• No antibiotics · Helsinki University Central Hospital · Non-steroidal anti-inflammatory · Pain management
  This drug works by blocking the action of a specific enzyme.
• Celebrex · Pfizer Inc. (originally Searle/Pharmacia) · Nonsteroidal Anti-inflammatory Drug [EPC] · Immunology
  Celecoxib works by inhibiting COX-2 to reduce prostaglandin synthesis, thereby decreasing pain, inflammation, and fever.
• Oral tablets of Alphintern® · Ain Shams University · Non-steroidal anti-inflammatory drug (NSAID) · Rheumatology
  Alphintern is a synthetic derivative of a natural compound that inhibits the activity of a specific enzyme.

Phase 3 pipeline (8)

• acetaminophen plus ibuprofen · Nova Scotia Health Authority · NSAID · Pain management
  Acetaminophen works by inhibiting the production of prostaglandins, which are chemicals that cause pain and fever, while ibuprofen works by inhibiting the enzyme COX-2, which is involved in the production of prostaglandins.
• Placebo to etoricoxib · Organon and Co · NSAID · Rheumatology
  Etoricoxib is a nonsteroidal anti-inflammatory drug (NSAID) that selectively inhibits COX-2, reducing prostaglandin synthesis and inflammation.
• MK0663, etoricoxib · Organon and Co · COX-2 inhibitor · Rheumatology
  Etoricoxib is a nonsteroidal anti-inflammatory drug (NSAID) that selectively inhibits COX-2, reducing prostaglandin synthesis and inflammation.
• Toragesic® · Apsen Farmaceutica S.A. · NSAID · Pain management
  Toragesic is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting prostaglandin synthesis.
• Vehicle Diclofenac Sodium Topical Gel · Amneal Pharmaceuticals, LLC · NSAID · Pain Management
  Diclofenac sodium works by inhibiting the enzyme cyclooxygenase (COX), which is involved in the production of prostaglandins, leading to reduced inflammation and pain.
• PIOLIN® · Phytopharm Consulting Brazil · Selective enzyme inhibitor · Rheumatology
  PIOLIN is a small molecule that acts as a selective inhibitor of the enzyme responsible for the production of a key inflammatory mediator.
• Physician's-Choice · Pfizer · small molecule · Oncology
  Physician's-Choice is a medication that works by inhibiting the activity of a specific enzyme.
• diclofenac diethylamine, DDEA 2.32% gel · Novartis · NSAID · Rheumatology
  Diclofenac diethylamine works by inhibiting the enzyme cyclooxygenase (COX), which is involved in the production of prostaglandins, leading to a reduction in inflammation and pain.

Phase 2 pipeline (12)

• ATB-346 mid-dose · Antibe Therapeutics Inc. · NSAID · Pain
  ATB-346 mid-dose is a nonsteroidal anti-inflammatory drug (NSAID) that selectively targets COX-2 to reduce gastrointestinal toxicity.
• Paracetamol hot drink · GlaxoSmithKline · Non-opioid analgesic · Pain management
  Paracetamol acts as an inhibitor of COX-2 enzyme.
• BL1107 High dose · Bausch & Lomb Incorporated · Anti-inflammatory · Ophthalmology
  BL1107 High dose is an anti-inflammatory agent.
• Diclofenac Sodium Active Topical Patch 2 · Noven Pharmaceuticals, Inc. · NSAID · Pain Management
  Diclofenac Sodium is a non-selective COX-2 inhibitor.
• Diclofenac Sodium Active Topical Patch 1 · Noven Pharmaceuticals, Inc. · NSAID · Pain Management
  Diclofenac Sodium is a non-selective COX-2 inhibitor.
• Diclofenac Capsules high dose · Iroko Pharmaceuticals, LLC · NSAID · Rheumatology
  Diclofenac works by inhibiting the enzyme cyclooxygenase (COX), which is involved in the production of prostaglandins, leading to reduced inflammation and pain.
• ATB-346 standard dose · Antibe Therapeutics Inc. · NSAID · Pain
  ATB-346 is a nonsteroidal anti-inflammatory drug (NSAID) that selectively targets COX-2 to reduce gastrointestinal toxicity.
• Celecoxib, COX-2 inhibitor; oral · Pfizer · COX-2 inhibitor · Osteoarthritis, Rheumatoid Arthritis, Pain
  Celecoxib selectively inhibits COX-2, an enzyme involved in inflammation and pain.
• Ketoprofen in Transfersome · IDEA AG · NSAID · Pain Management
  Inhibits COX-2
• Ibuvix® - ibuprofen · Apsen Farmaceutica S.A. · NSAID · Oncology
  Inhibits COX-2 enzyme
• ATB-346 low dose · Antibe Therapeutics Inc. · NSAID · Pain
  ATB-346 low dose is a nonsteroidal anti-inflammatory drug (NSAID) that selectively targets COX-2 to reduce gastrointestinal toxicity.
• Diclofenac Capsules low dose · Iroko Pharmaceuticals, LLC · NSAID · Rheumatology
  Diclofenac works by inhibiting the enzyme cyclooxygenase (COX), which is involved in the production of prostaglandins, leading to reduced inflammation and pain.

Phase 1 pipeline (1)

• Advil PM Liqui-Gels · HALEON · NSAID · Pain Management
  Ibuprofen is a non-selective COX-2 inhibitor.