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Naproxen(drug)
Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits the enzyme cyclooxygenase (COX), leading to a reduction in prostaglandin synthesis and subsequent inflammation.
Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits the enzyme cyclooxygenase (COX), leading to a reduction in prostaglandin synthesis and subsequent inflammation. Used for Rheumatoid arthritis, Osteoarthritis, Ankylosing spondylitis.
At a glance
| Generic name | Naproxen(drug) |
|---|---|
| Also known as | Naprosyn |
| Sponsor | Chinese University of Hong Kong |
| Drug class | NSAID |
| Target | COX |
| Modality | Small molecule |
| Therapeutic area | Rheumatology, Pain Management |
| Phase | Phase 3 |
Mechanism of action
This inhibition of COX enzymes results in a decrease in the production of prostaglandins, which are key mediators of inflammation and pain. As a result, naproxen is effective in reducing inflammation, pain, and fever in various conditions.
Approved indications
- Rheumatoid arthritis
- Osteoarthritis
- Ankylosing spondylitis
- Fever reduction
Common side effects
- Gastrointestinal upset
- Headache
- Dizziness
- Nausea
- Vomiting
- Abdominal pain
- Diarrhea
- Constipation
- Fatigue
- Insomnia
Key clinical trials
- Efficacy of Chemically Distinct Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) and Pain Phenotypes in Adhesive Capsulitis (NA)
- Study of Nonsteroidal Anti-inflammatory Drugs in People With Painful Knee Osteoarthritis (PHASE4)
- A Study of SJP-001 in Comparison With Fexofenadine and Naproxen Administered With Alcohol (PHASE1, PHASE2)
- Non-Steroidal Anti-Inflammatory Drug (NSAID) Response and Central Sensitization of Pain in Women With Dysmenorrhea (PHASE4)
- Suzetrigine Versus Usual-care Opioids for Postop Pain in Sports (PHASE4)
- Efficacy and Safety of MT-5547 in Patients With Osteoarthritis Accompanied by Moderate to Severe Pain (PHASE2, PHASE3)
- Effect of Extracorporeal Shock Wave Therapy (ESWT) and Phonophoresis Treatment in Patients With Lateral Epicondylitis (NA)
- Accessible Acupuncture for the Warrior With Acute Low Back Pain (NA)
Primary sources
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| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |