Last reviewed · How we verify
Test naproxen sodium tablet
Naproxen sodium is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the enzyme cyclooxygenase (COX), which is responsible for producing prostaglandins that cause pain and inflammation.
Naproxen sodium is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the enzyme cyclooxygenase (COX), which is responsible for producing prostaglandins that cause pain and inflammation. Used for Relief of pain, inflammation, and fever, Treatment of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
At a glance
| Generic name | Test naproxen sodium tablet |
|---|---|
| Also known as | Test NPX tablet |
| Sponsor | Johnson & Johnson Consumer Inc., McNeil Consumer Healthcare Division |
| Drug class | NSAID |
| Target | COX |
| Modality | Small molecule |
| Therapeutic area | Pain management, Inflammation |
| Phase | Phase 3 |
Mechanism of action
By inhibiting COX, naproxen sodium reduces the production of prostaglandins, leading to a decrease in pain and inflammation. This mechanism of action is similar to other NSAIDs, such as ibuprofen and aspirin.
Approved indications
- Relief of pain, inflammation, and fever
- Treatment of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis
Common side effects
- Gastrointestinal upset
- Headache
- Dizziness
- Nausea
- Vomiting
- Abdominal pain
- Diarrhea
- Constipation
- Flatulence
- Rash
Key clinical trials
- Study of Sumatriptan Naproxen Sodium Succinate Tablets for the Treatment of Acute Migraine Attacks (PHASE3)
- Copper IUD Treatment Observation Study (PHASE4)
- Efficacy and Safety Study of a Test Naproxen Sodium 220mg Tablet in Postoperative Dental Pain (PHASE3)
- A Study to Assess Bioquivalence Between a Novel Naproxen Sodium 275 mg Film-coated Tablet and Nalgesin Naproxen Sodium 275 mg Film-coated Tablet in Healthy Adult Volunteers (PHASE1)
- A Pharmacokinetic Trial of Naproxen Sodium and Diphenhydramine Hydrochloride Soft Capsules Versus Naproxen Sodium and Diphenhydramine Hydrochloride Tablets in Healthy Adult Subjects Under Fed Conditions (PHASE1)
- A Pharmacokinetic Trial of Naproxen Sodium and Diphenhydramine Hydrochloride Soft Capsules Versus Naproxen Sodium and Diphenhydramine Hydrochloride Tablets in Healthy Adult Subjects (PHASE1)
- Naproxen Sodium (2 x 220 mg) Fasted Comparative Bioavailability Study (PHASE1)
- A Study to Evaluate the Effect of Analgesics on a Walking Model of Knee Pain (0000-105)(COMPLETED) (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |