COX — Drug Target

All drugs that target COX — marketed and clinical-stage. Includes 3 drug classes acting on this target.

Drug classes

Nonsteroidal anti-inflammatory drug (NSAID) · NSAID · Non-opioid analgesic

Phase 3 pipeline (8)

• acetylsalicyclic acid (ASA) · Sanofi · Nonsteroidal anti-inflammatory drug (NSAID) · Cardiovascular
  Acetylsalicylic acid (ASA) works by inhibiting the enzyme cyclooxygenase (COX), which is involved in the production of prostaglandins and thromboxanes.
• benzydamine HCl · Prince of Songkla University · NSAID · Pain management
  Benzydamine HCl is a nonsteroidal anti-inflammatory drug (NSAID) that acts as a cyclooxygenase (COX) inhibitor.
• Test naproxen sodium tablet · Johnson & Johnson Consumer Inc., McNeil Consumer Healthcare Division · NSAID · Pain management, Inflammation
  Naproxen sodium is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the enzyme cyclooxygenase (COX), which is responsible for producing prostaglandins that cause pain and inflammation.
• aspirin continuation · Seoul National University Hospital · NSAID · Cardiovascular
  Aspirin continuation works by inhibiting the enzyme cyclooxygenase, which is involved in the production of prostaglandins and thromboxanes, leading to a decrease in platelet aggregation and blood clot formation.
• aspirin intake · University Hospital, Rouen · Nonsteroidal anti-inflammatory drug (NSAID) · Cardiovascular
  Aspirin works by inhibiting the enzyme cyclooxygenase (COX), which is involved in the production of prostaglandins and thromboxanes.
• Naproxen(drug) · Chinese University of Hong Kong · NSAID · Rheumatology, Pain Management
  Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits the enzyme cyclooxygenase (COX), leading to a reduction in prostaglandin synthesis and subsequent inflammation.
• Voltaren Topical Gel, 1% · Amneal Pharmaceuticals, LLC · NSAID · Musculoskeletal
  Voltaren Topical Gel, 1% works by reducing inflammation and pain through the inhibition of prostaglandin synthesis.
• Test acetaminophen · Johnson & Johnson Consumer Inc., McNeil Consumer Healthcare Division · Non-opioid analgesic · Pain relief
  Acetaminophen works by inhibiting the production of prostaglandins, which are chemicals that cause pain and fever.

Phase 2 pipeline (1)

• Intravenous Ketorolac Tromethamine · Oman Medical Speciality Board · NSAID · Pain Management
  Intravenous Ketorolac Tromethamine is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the enzyme cyclooxygenase (COX), which is involved in the production of prostaglandins, leading to reduced inflammation and pain.

Phase 1 pipeline (1)

• Advil PM Liqui-Gels Minis · HALEON · NSAID · Pain Management
  Acetaminophen is a non-selective COX inhibitor.