Last reviewed 2026-04-23 · How we verify

aspirin intake

Aspirin works by inhibiting the enzyme cyclooxygenase (COX), which is involved in the production of prostaglandins and thromboxanes.

Aspirin works by inhibiting the enzyme cyclooxygenase (COX), which is involved in the production of prostaglandins and thromboxanes. Used for Prevention of cardiovascular disease and stroke, Treatment of pain and inflammation.

At a glance

Mechanism of action

This inhibition leads to a decrease in the production of prostaglandins, which are responsible for pain and inflammation, and thromboxanes, which are involved in blood clotting. As a result, aspirin has anti-inflammatory, analgesic, and antiplatelet effects.

Approved indications

• Prevention of cardiovascular disease and stroke
• Treatment of pain and inflammation

Common side effects

• Gastrointestinal upset
• Bleeding
• Allergic reactions

Key clinical trials

• IRELAnD: Investigating the Role of Early Low-dose Aspirin in Diabetes (PHASE3)
• Helping Osteoarthritis Patients to Walk With NSAID (PHASE4)
• Study on Aspirin Versus Placebo in Resected Colon Cancer With PI3K Mutation Stage III or II High Risk (PHASE3)
• Comparative Effects of Aspirin and SGLT2 Inhibitors on Liver Enzymes, Lipid Profile, and FibroScan Findings in Non-Alcoholic Fatty Liver Disease (NA)
• ASPirin in Immune thRombocytopenia Patients With Cardiovascular disEase (PHASE2)
• Assessment of Oral Caffeine Intake in Changing the Severity of Acute Migraine Attack Using VAS Score Among Patients Attending Headache and Neurology Outpatients Clinic of Ainshams University Hospitals (PHASE4)
• Sleep and Inflammatory Resolution Pathway (EARLY_PHASE1)
• Aspirin® Plus Rivaroxaban Versus Rivaroxaban Alone for the Prevention of Venous Stent Thrombosis in Patients With PTS (PHASE2)

Primary sources

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