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Placebo to ibuprofen
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the enzyme cyclooxygenase (COX), which is responsible for producing prostaglandins that cause pain and inflammation.
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the enzyme cyclooxygenase (COX), which is responsible for producing prostaglandins that cause pain and inflammation. Used for Relief of pain and inflammation in osteoarthritis, rheumatoid arthritis, and other conditions.
At a glance
| Generic name | Placebo to ibuprofen |
|---|---|
| Also known as | Placebo |
| Sponsor | Organon and Co |
| Drug class | NSAID |
| Target | COX-1 and COX-2 |
| Modality | Small molecule |
| Therapeutic area | Pain management, Inflammation |
| Phase | Phase 3 |
Mechanism of action
Ibuprofen specifically inhibits COX-1 and COX-2 enzymes, leading to a decrease in prostaglandin production and subsequent reduction in pain and inflammation. This mechanism of action is responsible for its analgesic, antipyretic, and anti-inflammatory effects.
Approved indications
- Relief of pain and inflammation in osteoarthritis, rheumatoid arthritis, and other conditions
Common side effects
- Gastrointestinal upset
- Headache
- Dizziness
Key clinical trials
- Jaw Muscle Pain Post Wisdom Molar Surgery (PHASE2)
- Paracervical Block With Combined Ketorolac and Lidocaine for Osmotic Dilator Placement (PHASE2)
- Open-label Placebo (COLP) for Pain in Adolescent Idiopathic Scoliosis (AIS) Surgery+Surgical Treatment of Idiopathic Scoliosis (NA)
- Preemptive Analgesia for Pain and Anxiety Control in Children With MIH (NA)
- Ibuprofen and Biomarkers of Acute Kidney Injury After Running in the Heat (PHASE1)
- Evaluating Bone Marrow Cell Transplant for Treating Cerebral Palsy From Brain Hypoxia (PHASE2)
- TENS Unit To Decrease Pain After Laminaria Insertion (NA)
- Co-administration of Acetaminophen With Ibuprofen to Improve Duct-Related Outcomes in Extremely Premature Infants (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Placebo to ibuprofen CI brief — competitive landscape report
- Placebo to ibuprofen updates RSS · CI watch RSS
- Organon and Co portfolio CI