Organon and Co

Quick facts

Marketed products

• 20-mg Desloratadine
• Amlodipine camsylate · Cardiovascular
  Amlodipine camsylate blocks L-type calcium channels in vascular smooth muscle and cardiac tissue, reducing calcium influx and causing vasodilation and decreased blood pressure.
• Asmanex twisthaler
• Atorvastatin 10 mg
• Atorvastatin 80 mg
• Cetirizine (Zyrtec) · Immunology / Allergy
  Cetirizine is a selective H1-receptor antagonist that blocks histamine binding to H1 receptors on cells, preventing allergic symptoms.
• Comparator: atorvastatin · Cardiovascular
  Atorvastatin inhibits HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, thereby reducing LDL cholesterol levels.
• Comparator: carvedilol · Cardiovascular
  Carvedilol is a non-selective beta-adrenergic receptor antagonist with alpha-1 blocking activity that reduces heart rate, blood pressure, and cardiac workload.
• Comparator: Montelukast · Respiratory / Immunology
  Montelukast blocks cysteinyl leukotriene receptors (CysLT1) on airway and immune cells, preventing leukotriene-mediated inflammation and bronchoconstriction.
• Desloratadine 5 mg
• Desloratadine placebo tablet
  This is a placebo tablet containing no active pharmaceutical ingredient and therefore has no mechanistic effect.
• Double Atorvastatin · Cardiovascular
  Double Atorvastatin is a statin that inhibits HMG-CoA reductase to reduce cholesterol synthesis and lower LDL cholesterol levels.
• Etoricoxib 90 mg
• Ezetimibe + Atorvastatin · Cardiovascular
  This combination reduces cholesterol by blocking intestinal cholesterol absorption (ezetimibe) and inhibiting HMG-CoA reductase to decrease hepatic cholesterol synthesis (atorvastatin).
• Ezetimibe + Simvastatin · Cardiovascular
  Ezetimibe and simvastatin work together to lower cholesterol by blocking intestinal cholesterol absorption and inhibiting hepatic cholesterol synthesis.
• fluticasone nasal spray
• fluticasone propionate hydrofluoroalkane (HFA) · Immunology
  Fluticasone propionate HFA is a potent inhaled corticosteroid that reduces airway inflammation by binding to glucocorticoid receptors.
• FOSAMAX PLUS · Bone health / Osteoporosis
  FOSAMAX PLUS combines alendronate (a bisphosphonate) with cholecalciferol (vitamin D3) to inhibit bone resorption and improve calcium absorption.
• FOSAMAX PLUS D · Bone metabolism / Osteoporosis
  FOSAMAX PLUS D combines alendronate (a bisphosphonate that inhibits bone resorption) with cholecalciferol (vitamin D3) to prevent and treat osteoporosis while ensuring adequate vitamin D status.
• Losartan (+) amlodipine · Cardiovascular
  This combination blocks angiotensin II receptors and calcium channels to reduce blood pressure through vasodilation and decreased vascular resistance.
• low-dose estradiol/noresterone · Contraception / Women's Health
  Low-dose estradiol and noresterone work together as hormonal contraceptives by suppressing ovulation and altering cervical mucus and endometrial conditions to prevent pregnancy.
• MK0476; montelukast sodium · Respiratory / Immunology
  Montelukast sodium blocks cysteinyl leukotriene receptors (CysLT1) on airway and inflammatory cells, preventing leukotriene-mediated bronchoconstriction and inflammation.
• Mometasone furoate dry powder inhaler
• Mometasone Furoate MDI 200 mcg
• mometasone furoate nasal spray
• Montelukast chewable tablets
• Other Statin · Cardiovascular
  Statins inhibit HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, thereby reducing LDL cholesterol levels.
• Phase 3 NOMAC-E2 "Batch A" · Contraception / Gynecology
  NOMAC-E2 is a combined oral contraceptive containing norethisterone acetate (progestin) and ethinyl estradiol (estrogen) that prevents pregnancy through ovulation suppression and cervical mucus thickening.
• Placebo for etoricoxib
  A placebo contains no active pharmaceutical ingredient and produces no pharmacological effect.
• placebo nasal spray
  A placebo nasal spray contains no active pharmaceutical ingredient and produces therapeutic effects solely through the placebo effect.
• Placebo to budesonide inhaler · Respiratory/Pulmonology
  Budesonide is a corticosteroid that reduces airway inflammation by binding to glucocorticoid receptors and suppressing inflammatory cytokine production.
• Placebo to match amlodipine
  This is an inert placebo formulation designed to match the appearance and administration of amlodipine for use in blinded clinical trials.
• Placebo to montelukast chewable tablets · Respiratory / Immunology
  Montelukast is a leukotriene receptor antagonist that blocks cysteinyl leukotriene receptors to reduce airway inflammation and bronchoconstriction.
• Placebo vaginal ring · Contraception / Hormone Therapy
  A placebo vaginal ring delivers no active pharmaceutical ingredient and serves as an inert control device for clinical trials.
• Prednisone/Prednisolone · Immunology, Rheumatology, Endocrinology, Oncology (supportive), Respiratory, Dermatology
  Prednisone/prednisolone is a corticosteroid that binds to glucocorticoid receptors in the cytoplasm, translocates to the nucleus, and suppresses inflammatory gene expression and immune cell activation.
• raloxifen · Oncology
• recFSH
• Vehicle Cream · Dermatology
  Vehicle Cream is an inert topical formulation base used as a delivery system for active pharmaceutical ingredients in dermatological applications.
• VTAMA (tapinarof) cream, 1% · Dermatology / Immunology
  Tapinarof is an aryl hydrocarbon receptor (AhR) agonist that modulates immune responses in the skin to reduce inflammation and treat atopic dermatitis.
• Zyrtec® (cetirizine) · Allergy/Immunology
  Cetirizine is a selective H1-receptor antagonist that blocks histamine binding to H1 receptors on cells, preventing allergic symptoms.

Phase 3 pipeline

• A-Phase: tirofiban; Z-Phase simvastatin · Cardiovascular
  This is a combination therapy pairing tirofiban (a platelet glycoprotein IIb/IIIa inhibitor) with simvastatin (an HMG-CoA reductase inhibitor/statin) to provide dual antiplatelet and lipid-lowering effects.
• Albuterol/Salbutamol PRN · Respiratory
  Albuterol is a beta-2 adrenergic agonist that binds to beta-2 receptors on airway smooth muscle, causing rapid relaxation and bronchodilation.
• aminophylline hydrate
• Asenapine - Double Blind · Psychiatry/Neurology
  Asenapine is an atypical antipsychotic that blocks dopamine and serotonin receptors in the brain to reduce psychotic symptoms and mood disturbances.
• Asenapine - Open Label
• Atovastatin · Other
• Beclomethasone dipropionate nasal spray · Immunology / Respiratory
  Beclomethasone dipropionate is a corticosteroid that reduces inflammation in the nasal passages by suppressing immune cell activity and inflammatory mediator release.
• Budesonide DPI · Respiratory / Pulmonology
  Budesonide is a corticosteroid that reduces inflammation by binding to glucocorticoid receptors and suppressing immune and inflammatory responses in the lungs.
• CE/MPA · Contraception / Women's Health
  CE/MPA is a combined oral contraceptive containing conjugated estrogens and medroxyprogesterone acetate that prevents ovulation and alters the uterine environment to inhibit pregnancy.
• Chlorpheniramine maleate syrup · Allergy/Immunology
  Chlorpheniramine maleate blocks histamine H1 receptors to reduce allergic symptoms and itching.
• Comparator: acetaminophen + codeine · Pain Management
  Acetaminophen reduces fever and pain through central nervous system effects, while codeine is an opioid agonist that enhances analgesia and suppresses cough.
• Comparator: amlodipine besylate · Cardiovascular
  Amlodipine besylate is a calcium channel blocker that relaxes blood vessels and reduces blood pressure by inhibiting calcium influx into vascular smooth muscle cells.
• Comparator: celecoxib · Rheumatology / Pain Management
  Celecoxib selectively inhibits cyclooxygenase-2 (COX-2), reducing the production of prostaglandins that mediate inflammation and pain.
• Comparator: cetirizine · Immunology / Allergy
  Cetirizine is a selective H1-receptor antagonist that blocks histamine-mediated allergic responses without significant central nervous system penetration.
• Comparator: Diclofenac sodium · Pain Management, Rheumatology, Inflammation
  Diclofenac sodium inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation, pain, and fever.
• Comparator: etoricoxib · Rheumatology / Pain Management
  Etoricoxib selectively inhibits cyclooxygenase-2 (COX-2) to reduce prostaglandin production and inflammation.
• Comparator: ezetimibe and simvastatin · Cardiovascular
  This is a fixed-dose combination of ezetimibe (which blocks cholesterol absorption in the intestine) and simvastatin (which inhibits HMG-CoA reductase to reduce cholesterol synthesis), working synergistically to lower LDL cholesterol.
• Comparator: fenofibrate monotherapy · Cardiovascular
  Fenofibrate is a fibric acid derivative that activates peroxisome proliferator-activated receptor alpha (PPARα) to reduce triglycerides and increase HDL cholesterol.
• Comparator: fluvastatin · Cardiovascular
  Fluvastatin inhibits HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, thereby reducing LDL cholesterol levels.
• Comparator: ibuprofen · Pain Management, Inflammation, Rheumatology
  Ibuprofen inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation, pain, and fever.
• Comparator: loratadine · Allergy/Immunology
  Loratadine is a selective H1-receptor antagonist that blocks histamine-mediated allergic responses without significant central nervous system penetration.
• Comparator: losartan +/- HCTZ · Cardiovascular
  Losartan is an angiotensin II receptor antagonist that blocks vasoconstriction and aldosterone secretion to lower blood pressure; HCTZ is a thiazide diuretic that reduces fluid volume.
• Comparator: lovastatin · Cardiovascular
  Lovastatin inhibits HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, thereby reducing LDL cholesterol levels.
• Comparator: montelukast/loratadine · Immunology / Allergy / Respiratory
  This is a fixed-dose combination of montelukast (a cysteinyl leukotriene receptor antagonist) and loratadine (a selective H1-receptor antagonist) that reduces airway inflammation and blocks allergic mediators.
• Comparator: naproxen sodium · Pain Management, Rheumatology, Inflammation
  Naproxen sodium is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation, pain, and fever.
• Comparator: placebo, losartan, hydrochlorothiazide · Cardiovascular
  This drug is an angiotensin II receptor blocker (ARB) that lowers blood pressure by blocking the angiotensin II type 1 receptor, preventing vasoconstriction and aldosterone release.
• Comparator: Placebo to ezetimibe/simvastatin · Cardiovascular
  Ezetimibe/simvastatin is a combination that reduces cholesterol by blocking intestinal cholesterol absorption (ezetimibe) and inhibiting hepatic cholesterol synthesis (simvastatin).
• Comparator: pranlukast · Respiratory / Immunology
  Pranlukast is a cysteinyl leukotriene receptor antagonist that blocks the inflammatory effects of leukotrienes in the airways.
• Comparator: pravastatin · Cardiovascular
  Pravastatin inhibits HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, thereby reducing LDL cholesterol levels and cardiovascular risk.
• Comparator: Rizatriptan · Neurology
  Rizatriptan is a selective serotonin 5-HT1B/1D receptor agonist that constricts cranial blood vessels and inhibits neuropeptide release to relieve migraine headaches.
• Comparator: rizatriptan benzoate · Neurology
  Rizatriptan benzoate is a selective serotonin 5-HT1B/1D receptor agonist that constricts cranial blood vessels and inhibits neuropeptide release to relieve migraine headaches.
• Comparator: Salmeterol · Respiratory
  Salmeterol is a long-acting beta-2 adrenergic agonist that binds to beta-2 receptors on airway smooth muscle to cause bronchodilation and improve airflow.
• Comparator: simvastatin · Cardiovascular
  Simvastatin inhibits HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, thereby reducing LDL cholesterol levels.
• Comparator: statins · Cardiovascular
  Statins inhibit HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, thereby reducing LDL cholesterol levels.
• Comparator: sumatriptan · Neurology
  Sumatriptan is a selective serotonin 5-HT1B/1D receptor agonist that constricts cranial blood vessels and inhibits neuropeptide release to relieve migraine headaches.
• Comparator: Usual Care
  Usual Care is a comparator arm representing standard clinical management without the investigational intervention.
• Comparators: simvastatin and ezetimibe · Cardiovascular
  This is a combination therapy using simvastatin (a statin that inhibits HMG-CoA reductase) and ezetimibe (which blocks cholesterol absorption in the intestine) to lower LDL cholesterol through dual mechanisms.
• Desloratadine (Clarinex) · Immunology / Allergy
  Desloratadine is a selective histamine H1-receptor antagonist that blocks histamine-mediated allergic responses without significant central nervous system penetration.
• DRSP-EE · Contraception / Gynecology
  DRSP-EE is a combined oral contraceptive containing drospirenone (a progestin) and ethinyl estradiol (an estrogen) that prevents ovulation and alters cervical mucus to inhibit fertilization.
• Duration of Treatment: 3 months · Gynecology
  This drug works by inhibiting the activity of a specific enzyme.

Phase 2 pipeline

• E6005
• Etonogestrel-releasing IUS · Women's Health
  Etonogestrel-releasing IUS works by releasing a hormone that prevents ovulation and thickens cervical mucus to prevent sperm from reaching the egg.
• etonogestrel with testosterone undecanoate
• etorocoxib · Other
• Follitropin beta injection · Oncology
  Stimulates the production of follicle-stimulating hormone (FSH)
• Formoterol Fumarate DPI
• Hypolipemics · Other
• INEGY · Women's Health
  Selective estrogen receptor modulator
• MK-0476, montelukast sodium
• Mometasone Furoate DPI
• OG-6219
• Org 36286
• Other COX-2 inhibitor
• Other Cox-2 inhibitors
• Other Non-selective NSAIDs

Phase 1 pipeline

• Commercial NOMAC-E2
• E6005 0.05%
• E6005 0.2%
• Lyndiol®
• nomegestrol acetate and estradiol
• Phase 3 NOMAC-E2 "Batch B"

Competitive intelligence

For the full portfolio CI brief — phase mix, recent regulatory actions, upcoming PDUFA dates, patent timeline, class-overlap with competitors:

• Organon and Co portfolio CI brief
• Organon and Co pipeline updates RSS