Last reviewed 2026-04-23 · How we verify

Etonogestrel-releasing IUS

Etonogestrel-releasing IUS works by releasing a hormone that prevents ovulation and thickens cervical mucus to prevent sperm from reaching the egg.

Etonogestrel-releasing IUS works by releasing a hormone that prevents ovulation and thickens cervical mucus to prevent sperm from reaching the egg. Used for Contraception for up to 5 years.

At a glance

Mechanism of action

The etonogestrel-releasing intrauterine system (IUS) is a type of hormonal contraceptive that releases a small amount of the hormone etonogestrel, a form of progesterone, into the uterus. This hormone prevents ovulation and thickens cervical mucus, making it difficult for sperm to reach the egg. The IUS is a long-acting reversible contraceptive method that can be used for up to 5 years.

Approved indications

• Contraception for up to 5 years

Common side effects

• Irregular menstrual bleeding
• Headache
• Breast tenderness

Key clinical trials

• An Explorative Trial to Explore the Safety, Acceptability and Vaginal Bleeding Pattern of Three Etonogestrel-releasing Medicated Intrauterine Systems (Study P06060) (PHASE2)
• Duration of Use of Highly Effective Reversible Contraception
• Acceptability and Continuation Rate of Implanon in a Brazilian Public Sector (PHASE4)
• The Effect of Hormonal Contraceptives on Breast-milk Production and Infant Growth (PHASE4)

Primary sources

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Competitive intelligence

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