{"id":"etonogestrel-releasing-ius","safety":{"commonSideEffects":[{"rate":"null","effect":"Irregular menstrual bleeding"},{"rate":"null","effect":"Headache"},{"rate":"null","effect":"Breast tenderness"}]},"_chembl":{"chemblId":"CHEMBL1531","moleculeType":"Small molecule","molecularWeight":"324.46"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"The etonogestrel-releasing intrauterine system (IUS) is a type of hormonal contraceptive that releases a small amount of the hormone etonogestrel, a form of progesterone, into the uterus. This hormone prevents ovulation and thickens cervical mucus, making it difficult for sperm to reach the egg. The IUS is a long-acting reversible contraceptive method that can be used for up to 5 years.","oneSentence":"Etonogestrel-releasing IUS works by releasing a hormone that prevents ovulation and thickens cervical mucus to prevent sperm from reaching the egg.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T03:59:55.733Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Contraception for up to 5 years"}]},"trialDetails":[{"nctId":"NCT00967746","phase":"PHASE2","title":"An Explorative Trial to Explore the Safety, Acceptability and Vaginal Bleeding Pattern of Three Etonogestrel-releasing Medicated Intrauterine Systems (Study P06060)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2009-11","conditions":"Contraception","enrollment":84},{"nctId":"NCT02414919","phase":"","title":"Duration of Use of Highly Effective Reversible Contraception","status":"COMPLETED","sponsor":"Bayer","startDate":"2015-04-01","conditions":"Pregnancy","enrollment":13880},{"nctId":"NCT01392157","phase":"PHASE4","title":"Acceptability and Continuation Rate of Implanon in a Brazilian Public Sector","status":"COMPLETED","sponsor":"University of Campinas, Brazil","startDate":"2011-06","conditions":"Contraceptive Usage, Bleeding Due to Intrauterine Contraceptive Device","enrollment":300},{"nctId":"NCT01388582","phase":"PHASE4","title":"The Effect of Hormonal Contraceptives on Breast-milk Production and Infant Growth","status":"COMPLETED","sponsor":"University of Campinas, Brazil","startDate":"2011-04","conditions":"Underweight","enrollment":40}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":12,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["SCH 900342","ORG 299001"],"phase":"phase_2","status":"active","brandName":"Etonogestrel-releasing IUS","genericName":"Etonogestrel-releasing IUS","companyName":"Organon and Co","companyId":"organon-and-co","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Etonogestrel-releasing IUS works by releasing a hormone that prevents ovulation and thickens cervical mucus to prevent sperm from reaching the egg. Used for Contraception for up to 5 years.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}