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low-dose estradiol/noresterone
Low-dose estradiol and noresterone work together as hormonal contraceptives by suppressing ovulation and altering cervical mucus and endometrial conditions to prevent pregnancy.
Low-dose estradiol and noresterone work together as hormonal contraceptives by suppressing ovulation and altering cervical mucus and endometrial conditions to prevent pregnancy. Used for Contraception, Regulation of menstrual cycles.
At a glance
| Generic name | low-dose estradiol/noresterone |
|---|---|
| Also known as | Activelle® |
| Sponsor | Organon and Co |
| Drug class | Oral contraceptive (combined estrogen-progestin) |
| Target | Estrogen receptors (ER-α, ER-β) and progesterone receptors (PR) |
| Modality | Small molecule |
| Therapeutic area | Contraception / Women's Health |
| Phase | FDA-approved |
Mechanism of action
Estradiol and noresterone are synthetic or bioidentical hormones that inhibit the hypothalamic-pituitary-ovarian axis, preventing the surge of luteinizing hormone (LH) needed for ovulation. Additionally, they thicken cervical mucus to impede sperm transport and thin the endometrium to reduce implantation likelihood. The low-dose formulation aims to minimize systemic hormone exposure while maintaining contraceptive efficacy.
Approved indications
- Contraception
- Regulation of menstrual cycles
Common side effects
- Nausea
- Headache
- Breast tenderness
- Breakthrough bleeding
- Mood changes
- Venous thromboembolism
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- low-dose estradiol/noresterone CI brief — competitive landscape report
- low-dose estradiol/noresterone updates RSS · CI watch RSS
- Organon and Co portfolio CI