{"id":"low-dose-estradiol-noresterone","safety":{"commonSideEffects":[{"rate":"10-15","effect":"Nausea"},{"rate":"5-10","effect":"Headache"},{"rate":"5-10","effect":"Breast tenderness"},{"rate":"5-15","effect":"Breakthrough bleeding"},{"rate":"5","effect":"Mood changes"},{"rate":"0.3-0.4","effect":"Venous thromboembolism"}]},"_chembl":{"chemblId":"CHEMBL1511","moleculeType":"Small molecule","molecularWeight":"356.51"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Estradiol and noresterone are synthetic or bioidentical hormones that inhibit the hypothalamic-pituitary-ovarian axis, preventing the surge of luteinizing hormone (LH) needed for ovulation. Additionally, they thicken cervical mucus to impede sperm transport and thin the endometrium to reduce implantation likelihood. The low-dose formulation aims to minimize systemic hormone exposure while maintaining contraceptive efficacy.","oneSentence":"Low-dose estradiol and noresterone work together as hormonal contraceptives by suppressing ovulation and altering cervical mucus and endometrial conditions to prevent pregnancy.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:53:13.570Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Contraception"},{"name":"Regulation of menstrual cycles"}]},"trialDetails":[{"nctId":"NCT00431093","phase":"PHASE4","title":"Trial to Compare the Effects of Tibolone (Livial®) and Continuous Combined Low-Dose Estradiol/Noresterone (Activelle®)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2002-11","conditions":"Menopause","enrollment":570}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Activelle®"],"phase":"marketed","status":"active","brandName":"low-dose estradiol/noresterone","genericName":"low-dose estradiol/noresterone","companyName":"Organon and Co","companyId":"organon-and-co","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Low-dose estradiol and noresterone work together as hormonal contraceptives by suppressing ovulation and altering cervical mucus and endometrial conditions to prevent pregnancy. Used for Contraception, Regulation of menstrual cycles.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}