Last reviewed 2026-04-23 · How we verify

ketoprofen in Diractin®

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation and pain.

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation and pain. Used for Rheumatoid arthritis, Osteoarthritis, Ankylosing spondylitis.

At a glance

Mechanism of action

Ketoprofen works by blocking the action of enzymes called cyclooxygenases, which are responsible for producing prostaglandins. Prostaglandins are hormone-like substances that cause pain, inflammation, and fever. By inhibiting these enzymes, ketoprofen reduces the production of prostaglandins, leading to decreased inflammation and pain.

Approved indications

• Rheumatoid arthritis
• Osteoarthritis
• Ankylosing spondylitis

Common side effects

• Gastrointestinal upset
• Dizziness
• Headache

Key clinical trials

• Safety and Efficacy of Two Dosages of Diractin® in Osteoarthritis (OA) (PHASE3)
• Study of Safety and Efficacy of Diractin® for the Treatment of Osteoarthritis (OA) of the Knee (PHASE3)
• Multi-Centre, Open-Label, Two Segment, Study Comparing Plasma Pharmacokinetics of Ketoprofen in Diractin® Alone to Diractin® Applied Concomitant With Heat or Moderate Exercise (PHASE1)

Primary sources

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Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

• ketoprofen in Diractin® CI brief — competitive landscape report
• ketoprofen in Diractin® updates RSS · CI watch RSS
• IDEA AG portfolio CI