{"id":"ketoprofen-in-diractin","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Gastrointestinal upset"},{"rate":"5-10%","effect":"Dizziness"},{"rate":"5-10%","effect":"Headache"}]},"_chembl":{"chemblId":"CHEMBL571","moleculeType":"Small molecule","molecularWeight":"254.29"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Ketoprofen works by blocking the action of enzymes called cyclooxygenases, which are responsible for producing prostaglandins. Prostaglandins are hormone-like substances that cause pain, inflammation, and fever. By inhibiting these enzymes, ketoprofen reduces the production of prostaglandins, leading to decreased inflammation and pain.","oneSentence":"Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation and pain.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:17:48.723Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Rheumatoid arthritis"},{"name":"Osteoarthritis"},{"name":"Ankylosing spondylitis"}]},"trialDetails":[{"nctId":"NCT00716547","phase":"PHASE3","title":"Safety and Efficacy of Two Dosages of Diractin® in Osteoarthritis (OA)","status":"COMPLETED","sponsor":"IDEA AG","startDate":"2008-05","conditions":"Osteoarthritis of the Knee","enrollment":1399},{"nctId":"NCT00722852","phase":"PHASE3","title":"Study of Safety and Efficacy of Diractin® for the Treatment of Osteoarthritis (OA) of the Knee","status":"COMPLETED","sponsor":"IDEA AG","startDate":"2008-06","conditions":"Osteoarthritis of the Knee","enrollment":555},{"nctId":"NCT00745264","phase":"PHASE1","title":"Multi-Centre, Open-Label, Two Segment, Study Comparing Plasma Pharmacokinetics of Ketoprofen in Diractin® Alone to Diractin® Applied Concomitant With Heat or Moderate Exercise","status":"COMPLETED","sponsor":"IDEA AG","startDate":"2007-10","conditions":"Pharmacokinetic","enrollment":80}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":5,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"ketoprofen in Diractin®","genericName":"ketoprofen in Diractin®","companyName":"IDEA AG","companyId":"idea-ag","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation and pain. Used for Rheumatoid arthritis, Osteoarthritis, Ankylosing spondylitis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}