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Indomethacin suppository
Indomethacin suppository is a Nonsteroidal anti-inflammatory drug (NSAID) Small molecule drug developed by Azienda USL Reggio Emilia - IRCCS. It is currently FDA-approved for Rheumatoid arthritis, Osteoarthritis, Ankylosing spondylitis. Also known as: Indomethacin, Indocid suppository, Indocin, Indocid.
Indomethacin inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation, pain, and fever.
Indomethacin suppository is a small molecule that acts as a cyclooxygenase inhibitor, which is a class of drugs that inhibit the enzyme cyclooxygenase. It has been studied for various conditions including pain, renal colic, and post-operative pancreatitis, among others.
At a glance
| Generic name | Indomethacin suppository |
|---|---|
| Also known as | Indomethacin, Indocid suppository, Indocin, Indocid, Indochron |
| Sponsor | Azienda USL Reggio Emilia - IRCCS |
| Drug class | Nonsteroidal anti-inflammatory drug (NSAID) |
| Target | COX-1 and COX-2 |
| Modality | Small molecule |
| Therapeutic area | Pain management, Rheumatology, Gastroenterology |
| Phase | FDA-approved |
Mechanism of action
As a non-selective nonsteroidal anti-inflammatory drug (NSAID), indomethacin blocks both COX-1 and COX-2 enzymes, which are responsible for producing prostaglandins that mediate inflammatory responses, pain signaling, and fever regulation. The suppository formulation delivers the drug rectally for systemic absorption, providing anti-inflammatory and analgesic effects. This mechanism makes it effective for various inflammatory and pain conditions.
Approved indications
- Rheumatoid arthritis
- Osteoarthritis
- Ankylosing spondylitis
- Acute pain and inflammation
- Patent ductus arteriosus (in neonates)
- Migraine headache
Common side effects
- Gastrointestinal irritation or ulceration
- Dyspepsia
- Headache
- Dizziness
- Nausea
- Rectal irritation (suppository formulation)
- Increased cardiovascular risk (chronic use)
- Renal impairment (chronic use)
Key clinical trials
- Prophylactic PS Placement to Prevent Pancreatitis After Endoscopic Transpapillary GPC for Cholelithiasis With Concomitant Choledocholithiasis (NA)
- Study Comparing Transobturator Cystocele vs. Anterior Vaginal RepairS (NA)
- Indian National Study to Assess Incidence and Severity of Post-ERCP Pancreatitis After Following SOP
- Low-Dose vs Standard-Dose Indomethacin for Preventing Post-ERCP Pancreatitis (PHASE4)
- Aggressive Intravenous Hydration With or Without Indometacin to Prevent Pancreatitis After Pancreatic Extracorporeal Shock Wave Lithotripsy (NA)
- Prophylaxis of Post-ERCP Acute Pancreatitis (PHASE3)
- Rectal Indomethacin as Early Treatment for Acute Pancreatitis (INDOMAP Trial) (PHASE4)
- Efficacy of Mepilex Lite Dressings in Treating Anal Pain (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Indomethacin suppository CI brief — competitive landscape report
- Indomethacin suppository updates RSS · CI watch RSS
- Azienda USL Reggio Emilia - IRCCS portfolio CI
Frequently asked questions about Indomethacin suppository
What is Indomethacin suppository?
How does Indomethacin suppository work?
What is Indomethacin suppository used for?
Who makes Indomethacin suppository?
Is Indomethacin suppository also known as anything else?
What drug class is Indomethacin suppository in?
What development phase is Indomethacin suppository in?
What are the side effects of Indomethacin suppository?
What does Indomethacin suppository target?
Related
- Drug class: All Nonsteroidal anti-inflammatory drug (NSAID) drugs
- Target: All drugs targeting COX-1 and COX-2
- Manufacturer: Azienda USL Reggio Emilia - IRCCS — full pipeline
- Therapeutic area: All drugs in Pain management, Rheumatology, Gastroenterology
- Indication: Drugs for Rheumatoid arthritis
- Indication: Drugs for Osteoarthritis
- Indication: Drugs for Ankylosing spondylitis
- Also known as: Indomethacin, Indocid suppository, Indocin, Indocid, Indochron
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing