Last reviewed 2026-04-19 · How we verify

Osteoarthritis

Approved treatments

• Sofenac
  Sofenac works by inhibiting the COX-2 enzyme, which reduces inflammation and pain.
• Magan
• Celebrex · Pfizer Inc. (originally Searle/Pharmacia)
  Celecoxib works by inhibiting COX-2 to reduce prostaglandin synthesis, thereby decreasing pain, inflammation, and fever.
• Sasapyrine
  Salsalate works by inhibiting the enzyme COX-1 and COX-2, which are responsible for producing prostaglandins.
• DEXIBUPROFEN
• Trilisate
  Trilisate works by blocking the production of prostaglandins, hormone-like substances that cause pain and inflammation.
• Afloxan
  Afloxan works by inhibiting the activity of enzymes called lipoxygenases, which play a role in the production of inflammatory mediators.
• Nalfon · Pharmaco
• Etofenamat · Ankara City Hospital Bilkent
• Loqoa · Taisho Pharmaceutical Co., Ltd.
• Ultram · Janssen
• Voltaren · Hisamitsu Pharmaceutical Co., Inc
• Etofen
  Etofenamate works by blocking the production of prostaglandins, which are chemicals that cause pain and inflammation.
• Eramin · Eli Lilly
• Indom · University of Trieste
• Joicela · Novartis Pharmaceuticals UK Limited
• Traxam
  Traxam works by blocking the production of prostaglandins, hormone-like substances that cause pain and inflammation.
• Acelex · CrystalGenomics
• Apazone
• Hifenac
• Lithobid · Generic (multiple manufacturers)
• Advil · Generic (originally Boots Group)
  Ibuprofen inhibits prostaglandin synthetase, reducing pain, fever, and inflammation.
• Norgesic · Endo
  Orphenadrine citrate centrally acts on brain stem to selectively block facilitatory reticular functions.
• Indocin Sr
  Indomethacin works by blocking the production of prostaglandins, which are hormone-like substances that cause pain and inflammation.
• IMRECOXIB · HengRui
• Lithium Carbonate
• Dolobid
• Feldene · Pfizer
  Feldene works by blocking the production of prostaglandins, hormone-like substances that cause pain and inflammation.
• Daypro · Solubiomix
• Orudis
• Lodine · Pfizer
• Arthrotec · Pfizer
• Relafen
• Meclofenamate
• Tolectin 600
• Mobic · Boehringer Ingelheim
  Meloxicam works by inhibiting the enzyme prostaglandin G/H synthase 2, which is involved in the production of prostaglandins that cause pain and inflammation.
• Ocufen · Pfizer
• celebrex · POZEN
• Vioxx · M.D. Anderson Cancer Center
• indometacin · Maastricht University Medical Center
• Meclofenamate · Memorial Sloan Kettering Cancer Center
• Aleve · Generic (originally Syntex)
  Reversibly inhibits COX-1 and COX-2 with a long half-life, providing sustained anti-inflammatory, analgesic, and antipyretic effects.

Clinical guidelines

• FDA label — 1L
  For relief of the signs and symptoms of osteoarthritis
• FDA label — any
  For the temporary relief of arthritis pain in the hand, wrist, elbow, foot, ankle, and knee. May take up to 7 days to work for arthritis pain; it is not for immediate relief. If no pain relief in 7 days, stop use.
• FDA label — any
  For the temporary relief of arthritis pain in the knee. May take up to 7 days to work for arthritis pain; it is not for immediate relief. If no pain relief in 7 days, stop use.

Competitive intelligence

For the full treatment-landscape CI brief — marketed leaders side-by-side, pipeline by phase, recent regulatory actions, sponsor landscape:

• Osteoarthritis patent landscape — cliff calendar, originator estates, attackable patents
• Osteoarthritis treatment landscape brief
• Osteoarthritis treatment updates RSS

Frequently asked questions about Osteoarthritis

Related

• Treatment landscape: Osteoarthritis patent cliff · Osteoarthritis CI report
• Treatment: Sofenac
• Treatment: Magan
• Treatment: Celebrex · Pfizer Inc. (originally Searle/Pharmacia)
• Treatment: Sasapyrine
• Treatment: DEXIBUPROFEN
• All diseases: Browse the disease index · Disease landscape hub

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing