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Ibuprofen Acid
Ibuprofen inhibits cyclooxygenase (COX) enzymes to reduce the production of prostaglandins, thereby decreasing inflammation, pain, and fever.
Ibuprofen inhibits cyclooxygenase (COX) enzymes to reduce the production of prostaglandins, thereby decreasing inflammation, pain, and fever. Used for Mild to moderate pain, Fever reduction, Inflammatory conditions (e.g., rheumatoid arthritis, osteoarthritis).
At a glance
| Generic name | Ibuprofen Acid |
|---|---|
| Sponsor | Reckitt Benckiser Healthcare (UK) Limited |
| Drug class | Nonsteroidal anti-inflammatory drug (NSAID) |
| Target | COX-1 and COX-2 |
| Modality | Small molecule |
| Therapeutic area | Pain Management, Inflammation |
| Phase | FDA-approved |
Mechanism of action
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that non-selectively inhibits both COX-1 and COX-2 enzymes. By blocking these enzymes, it reduces prostaglandin synthesis, which are key mediators of inflammation, pain signaling, and fever regulation. This mechanism makes it effective for mild to moderate pain and inflammatory conditions.
Approved indications
- Mild to moderate pain
- Fever reduction
- Inflammatory conditions (e.g., rheumatoid arthritis, osteoarthritis)
Common side effects
- Gastrointestinal upset (nausea, dyspepsia)
- Abdominal pain
- Headache
- Dizziness
- Increased risk of cardiovascular events (with chronic use)
- Increased risk of gastrointestinal bleeding (with chronic use)
Key clinical trials
- Efficacy of Chemically Distinct Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) and Pain Phenotypes in Adhesive Capsulitis (NA)
- Paracervical Block With Combined Ketorolac and Lidocaine for Osmotic Dilator Placement (PHASE2)
- Comparing Over the Counter Pain Medicines for Discomfort in Crohn's Disease (AVID-CD) (NA)
- A Bioequivalence Study of Advil Tablet (Mini) (Ibuprofen 200 mg) Versus Advil Tablet (Ibuprofen 200 mg) in Healthy Adult Subjects Under Fasted Conditions and Bioavailability Assessment of Advil Tablet (Mini) Under Fed Conditions (PHASE1)
- Open-Label Placebo for Non-Specific Pain in the ED (NA)
- Comparing Analgesic Regimen Effectiveness and Safety for Surgery for Kids Trial (PHASE4)
- Preemptive IV Ibuprofen for Neurocognitive Recovery and Analgesic Needs After Inguinal Hernia Surgery (PHASE4)
- Phase 2 Herniorrhaphy Study for Opioid Elimination (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Ibuprofen Acid CI brief — competitive landscape report
- Ibuprofen Acid updates RSS · CI watch RSS
- Reckitt Benckiser Healthcare (UK) Limited portfolio CI