{"id":"ibuprofen-acid","safety":{"commonSideEffects":[{"rate":"5-15","effect":"Gastrointestinal upset (nausea, dyspepsia)"},{"rate":"3-9","effect":"Abdominal pain"},{"rate":"2-5","effect":"Headache"},{"rate":"1-3","effect":"Dizziness"},{"rate":null,"effect":"Increased risk of cardiovascular events (with chronic use)"},{"rate":null,"effect":"Increased risk of gastrointestinal bleeding (with chronic use)"}]},"_chembl":{"chemblId":"CHEMBL521","moleculeType":"Small molecule","molecularWeight":"206.28"},"_dailymed":{"setId":"891a69a7-e004-c8c5-e053-2995a90ab49e","title":"CIMETIDINE 5% / IBUPROFEN 2% / SALICYLIC ACID 17% GEL [SINCERUS FLORIDA, LLC]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that non-selectively inhibits both COX-1 and COX-2 enzymes. By blocking these enzymes, it reduces prostaglandin synthesis, which are key mediators of inflammation, pain signaling, and fever regulation. This mechanism makes it effective for mild to moderate pain and inflammatory conditions.","oneSentence":"Ibuprofen inhibits cyclooxygenase (COX) enzymes to reduce the production of prostaglandins, thereby decreasing inflammation, pain, and fever.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T05:05:35.371Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Mild to moderate pain"},{"name":"Fever reduction"},{"name":"Inflammatory conditions (e.g., rheumatoid arthritis, osteoarthritis)"}]},"trialDetails":[{"nctId":"NCT07493226","phase":"NA","title":"Efficacy of Chemically Distinct Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) and Pain Phenotypes in Adhesive Capsulitis","status":"RECRUITING","sponsor":"Konya Beyhekim Training and Research Hospital","startDate":"2026-04-01","conditions":"Frozen Shoulder, Adhesive Capsulitis, Shoulder Pain","enrollment":120},{"nctId":"NCT07487246","phase":"PHASE2","title":"Paracervical Block With Combined Ketorolac and 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