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Standard ibuprofen treatment
Ibuprofen works by inhibiting the enzyme cyclooxygenase (COX), which is involved in the production of prostaglandins, leading to a reduction in inflammation and pain.
Ibuprofen works by inhibiting the enzyme cyclooxygenase (COX), which is involved in the production of prostaglandins, leading to a reduction in inflammation and pain. Used for Treatment of mild to moderate pain, Dysmenorrhea, Menstrual cramps, Osteoarthritis, Rheumatoid arthritis.
At a glance
| Generic name | Standard ibuprofen treatment |
|---|---|
| Sponsor | Fundacion para la Investigacion Biomedica del Hospital Universitario la Paz |
| Drug class | Nonsteroidal anti-inflammatory drug (NSAID) |
| Target | COX-1 and COX-2 |
| Modality | Small molecule |
| Therapeutic area | Pain management, Inflammation |
| Phase | Phase 3 |
Mechanism of action
Ibuprofen specifically inhibits COX-1 and COX-2 enzymes, which are responsible for the production of prostaglandins. This reduction in prostaglandin production leads to a decrease in inflammation and pain. Additionally, ibuprofen has a mild antiplatelet effect, which may contribute to its analgesic and anti-inflammatory effects.
Approved indications
- Treatment of mild to moderate pain, Dysmenorrhea, Menstrual cramps, Osteoarthritis, Rheumatoid arthritis
Common side effects
- Gastrointestinal upset
- Headache
- Dizziness
- Nausea
- Vomiting
Key clinical trials
- Paracervical Block With Combined Ketorolac and Lidocaine for Osmotic Dilator Placement (PHASE2)
- Two Post-Operative Pain Protocols at Discharge for Orthopaedic Patients (NA)
- Multimodal Exercise Therapy for Non-Surgical Intervention of Nonspecific Low Back Pain. (NA)
- Verbal Analgesia Versus Standard Care for Pain Control in Women With Primary Infertility Undergoing Office Hysteroscopy (NA)
- Initial Pain Management in Pediatric Pancreatitis: Opioid vs. Non-Opioid (PHASE2)
- TENS Unit To Decrease Pain After Laminaria Insertion (NA)
- Meloxicam in Mohs Micrographic Surgery (PHASE4)
- Co-administration of Acetaminophen With Ibuprofen to Improve Duct-Related Outcomes in Extremely Premature Infants (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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