{"id":"standard-ibuprofen-treatment","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Gastrointestinal upset"},{"rate":"10-20%","effect":"Headache"},{"rate":"5-10%","effect":"Dizziness"},{"rate":"5-10%","effect":"Nausea"},{"rate":"2-5%","effect":"Vomiting"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Ibuprofen specifically inhibits COX-1 and COX-2 enzymes, which are responsible for the production of prostaglandins. This reduction in prostaglandin production leads to a decrease in inflammation and pain. Additionally, ibuprofen has a mild antiplatelet effect, which may contribute to its analgesic and anti-inflammatory effects.","oneSentence":"Ibuprofen works by inhibiting the enzyme cyclooxygenase (COX), which is involved in the production of prostaglandins, leading to a reduction in inflammation and pain.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:36:19.714Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Treatment of mild to moderate pain, Dysmenorrhea, Menstrual cramps, Osteoarthritis, Rheumatoid arthritis"}]},"trialDetails":[{"nctId":"NCT07487246","phase":"PHASE2","title":"Paracervical Block With Combined Ketorolac and Lidocaine for Osmotic Dilator Placement","status":"NOT_YET_RECRUITING","sponsor":"Rush University Medical Center","startDate":"2026-05-01","conditions":"Pain Management, Abortion, Second Trimester Abortion","enrollment":76},{"nctId":"NCT07265557","phase":"NA","title":"Two Post-Operative Pain Protocols at Discharge for 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