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Ketoprofen Lysine Salt
Ketoprofen lysine salt is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis and provide analgesic, anti-inflammatory, and antipyretic effects.
Ketoprofen lysine salt is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis and provide analgesic, anti-inflammatory, and antipyretic effects. Used for Acute pain management, Postoperative pain, Migraine headache.
At a glance
| Generic name | Ketoprofen Lysine Salt |
|---|---|
| Also known as | KLS |
| Sponsor | Dompé Farmaceutici S.p.A |
| Drug class | Nonsteroidal anti-inflammatory drug (NSAID) |
| Target | COX-1 and COX-2 |
| Modality | Small molecule |
| Therapeutic area | Pain Management / Rheumatology |
| Phase | FDA-approved |
Mechanism of action
Ketoprofen is a propionic acid derivative NSAID that non-selectively inhibits both COX-1 and COX-2 enzymes, thereby decreasing production of prostaglandins and thromboxanes involved in inflammation, pain, and fever. The lysine salt formulation enhances solubility and absorption, allowing for faster onset of action compared to standard ketoprofen formulations, making it suitable for acute pain management.
Approved indications
- Acute pain management
- Postoperative pain
- Migraine headache
- Musculoskeletal pain and inflammation
Common side effects
- Gastrointestinal upset (dyspepsia, nausea)
- Headache
- Dizziness
- Gastric ulceration
- Renal impairment (with chronic use)
Key clinical trials
- A Study on Ketoprofen Lysine Salt (KLS) + Gabapentin (GABA) vs KLS to Investigate Their Pharmacodynamic in Healthy Males (PHASE1)
- A Study to Assess Efficacy and Tolerability of Ketoprofen 40 mg Granules vs Placebo (PHASE3)
- Crossover, Single Dose Randomized, Bioequivalence of Ketoprofen Lysine Salt Immediate Release vs Oral Solution (PHASE1)
- Bioequivalence of Ketoprofen Oral Gel vs Ketoprofen Lysine Salt as Granules for Oral Solution (PHASE1)
- Ketoprofen Lysine Salt as Mouthwash in Acute Phlogosis of the Pharyngeal Cavity Versus Benzidamine Hydrochloride (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Ketoprofen Lysine Salt CI brief — competitive landscape report
- Ketoprofen Lysine Salt updates RSS · CI watch RSS
- Dompé Farmaceutici S.p.A portfolio CI