{"id":"ketoprofen-lysine-salt","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset (dyspepsia, nausea)"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Gastric ulceration"},{"rate":null,"effect":"Renal impairment (with chronic use)"}]},"_chembl":{"chemblId":"CHEMBL4650345","moleculeType":"Small molecule","molecularWeight":"400.48"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ketoprofen is a propionic acid derivative NSAID that non-selectively inhibits both COX-1 and COX-2 enzymes, thereby decreasing production of prostaglandins and thromboxanes involved in inflammation, pain, and fever. The lysine salt formulation enhances solubility and absorption, allowing for faster onset of action compared to standard ketoprofen formulations, making it suitable for acute pain management.","oneSentence":"Ketoprofen lysine salt is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis and provide analgesic, anti-inflammatory, and antipyretic effects.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:51:02.249Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute pain management"},{"name":"Postoperative pain"},{"name":"Migraine headache"},{"name":"Musculoskeletal pain and inflammation"}]},"trialDetails":[{"nctId":"NCT04802967","phase":"PHASE1","title":"A Study on Ketoprofen Lysine Salt (KLS) + Gabapentin (GABA) vs KLS to Investigate Their Pharmacodynamic in Healthy Males","status":"COMPLETED","sponsor":"Dompé Farmaceutici S.p.A","startDate":"2021-02-08","conditions":"No Condition","enrollment":141},{"nctId":"NCT03836807","phase":"PHASE3","title":"A Study to Assess Efficacy and Tolerability of Ketoprofen 40 mg Granules vs Placebo","status":"COMPLETED","sponsor":"Dompé Farmaceutici S.p.A","startDate":"2018-04-04","conditions":"Acute Pain","enrollment":70},{"nctId":"NCT02350296","phase":"PHASE1","title":"Crossover, Single Dose Randomized, Bioequivalence of Ketoprofen Lysine Salt Immediate Release vs Oral Solution","status":"COMPLETED","sponsor":"Dompé Farmaceutici S.p.A","startDate":"2014-11-26","conditions":"Pain Disorders","enrollment":30},{"nctId":"NCT04678076","phase":"PHASE1","title":"Bioequivalence of Ketoprofen Oral Gel vs Ketoprofen Lysine Salt as Granules for Oral Solution","status":"COMPLETED","sponsor":"Aziende Chimiche Riunite Angelini Francesco S.p.A","startDate":"2018-07-23","conditions":"Healthy","enrollment":36},{"nctId":"NCT02178293","phase":"PHASE4","title":"Ketoprofen Lysine Salt as Mouthwash in Acute Phlogosis of the Pharyngeal Cavity Versus Benzidamine Hydrochloride","status":"COMPLETED","sponsor":"Boehringer Ingelheim","startDate":"1998-09","conditions":"Pharyngitis","enrollment":214}],"_emaApprovals":[],"_faersSignals":[{"count":1,"reaction":"JAUNDICE"},{"count":1,"reaction":"KOUNIS SYNDROME"}],"_approvalHistory":[],"publicationCount":47,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["KLS"],"phase":"marketed","status":"active","brandName":"Ketoprofen Lysine Salt","genericName":"Ketoprofen Lysine Salt","companyName":"Dompé Farmaceutici S.p.A","companyId":"domp-farmaceutici-s-p-a","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ketoprofen lysine salt is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis and provide analgesic, anti-inflammatory, and antipyretic effects. Used for Acute pain management, Postoperative pain, Migraine headache.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}