Last reviewed · How we verify
Intravenous ibuprofen
Intravenous ibuprofen inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation and pain.
Intravenous ibuprofen inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation and pain. Used for Fever reduction in hospitalized patients, Acute pain management in hospitalized patients.
At a glance
| Generic name | Intravenous ibuprofen |
|---|---|
| Also known as | IV ibuprofen, Caldolor, Pedea i.v., ibuprofen, Intravenous Acetaminophen |
| Sponsor | Biomendi S.A.U. |
| Drug class | Nonsteroidal anti-inflammatory drug (NSAID) |
| Target | COX-1 and COX-2 |
| Modality | Small molecule |
| Therapeutic area | Pain Management, Inflammation |
| Phase | FDA-approved |
Mechanism of action
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that blocks both COX-1 and COX-2 enzymes, which are responsible for producing prostaglandins that mediate inflammation, pain, and fever. The intravenous formulation provides rapid systemic delivery for acute pain and fever management in hospitalized patients who cannot take oral medication.
Approved indications
- Fever reduction in hospitalized patients
- Acute pain management in hospitalized patients
Common side effects
- Gastrointestinal bleeding
- Renal impairment
- Cardiovascular events
- Platelet dysfunction
Key clinical trials
- ERAS (Enhanced Recovery After Surgery) and Multimodal Analgesia in Laparoscopic Cholecystectomy
- Comparative Assessment of Oral Premedication Regimens in Pediatric Ambulatory Surgery (NA)
- Preemptive IV Ibuprofen for Neurocognitive Recovery and Analgesic Needs After Inguinal Hernia Surgery (PHASE4)
- Postoperative Analgesic Efficacy of SPSIPB in Anterior Cervical Discectomy (NA)
- HPV Vaccine PRGN-2009 Alone or in Combination With Anti-PDL1/TGF-Beta Trap (M7824) in Subjects With HPV Associated Cancers (PHASE1, PHASE2)
- Comparison of M-TAPA and TAP Blocks on Postoperative Analgesia in Laparoscopic Inguinal Hernia Surgeries (NA)
- Effect of Perioperative IV Ibuprofen on Cerebral Oxygenation and Postoperative Cognition During One-Lung Ventilation (NA)
- The Effect of Multimodal Pain Regimen on Use of Narcotics After Rotator Cuff Tear Repair (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |