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Diclofenac oral + Placebo Oral
Diclofenac oral + Placebo Oral is a Nonsteroidal anti-inflammatory drug (NSAID) Small molecule drug developed by Hospital de Clinicas de Porto Alegre. It is currently FDA-approved for Acute pain, Inflammatory conditions, Rheumatoid arthritis. Also known as: Diclofenac 50 mg oral tablet.
Diclofenac inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation and pain.
Diclofenac inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation and pain. Used for Acute pain, Inflammatory conditions, Rheumatoid arthritis.
At a glance
| Generic name | Diclofenac oral + Placebo Oral |
|---|---|
| Also known as | Diclofenac 50 mg oral tablet |
| Sponsor | Hospital de Clinicas de Porto Alegre |
| Drug class | Nonsteroidal anti-inflammatory drug (NSAID) |
| Target | COX-1 and COX-2 |
| Modality | Small molecule |
| Therapeutic area | Pain Management / Rheumatology |
| Phase | FDA-approved |
Mechanism of action
Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that non-selectively inhibits COX-1 and COX-2 enzymes. By blocking prostaglandin production, it reduces inflammatory mediators and provides analgesic and anti-inflammatory effects. This combination study pairs diclofenac with placebo to evaluate its efficacy in a clinical trial setting.
Approved indications
- Acute pain
- Inflammatory conditions
- Rheumatoid arthritis
Common side effects
- Gastrointestinal upset
- Dyspepsia
- Nausea
- Headache
- Dizziness
- Increased cardiovascular risk
- Renal impairment risk
Key clinical trials
- KF2022#4-trial: Effects of a Beta Blocker and NSAID on CYP Mediated Drug Metabolism (NA)
- The Effect of Three Different Medications on Anesthetic Success and Postoperative Pain (NA)
- Effect of Genetic Polymorphisms on Response to Preoperative NSAIDs in Endodontic Postoperative Pain Management (NA)
- Study of PHN131 in Patients After Surgery (PHASE2, PHASE3)
- Acute Low Back Pain. Topical Diclofenac and Oral Ibuprofen. (PHASE4)
- Combination of Diclofenac Potassium and Propolis in the Therapy of Oral Aphthosis (EARLY_PHASE1)
- Synergistic Effect Of Parenteral Diclofenac And Paracetamol In The Pain Management Of Acute Limb Injuries (PHASE4)
- COMPARISON OF EFFICACY OF DIFFERENT DRUG COMBINATIONS IN ACUTE SCIATICA (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Diclofenac oral + Placebo Oral CI brief — competitive landscape report
- Diclofenac oral + Placebo Oral updates RSS · CI watch RSS
- Hospital de Clinicas de Porto Alegre portfolio CI
Frequently asked questions about Diclofenac oral + Placebo Oral
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Related
- Drug class: All Nonsteroidal anti-inflammatory drug (NSAID) drugs
- Target: All drugs targeting COX-1 and COX-2
- Manufacturer: Hospital de Clinicas de Porto Alegre — full pipeline
- Therapeutic area: All drugs in Pain Management / Rheumatology
- Indication: Drugs for Acute pain
- Indication: Drugs for Inflammatory conditions
- Indication: Drugs for Rheumatoid arthritis
- Also known as: Diclofenac 50 mg oral tablet
- Compare: Diclofenac oral + Placebo Oral vs similar drugs
- Pricing: Diclofenac oral + Placebo Oral cost, discount & access