{"id":"diclofenac-oral-placebo-oral","safety":{"commonSideEffects":[{"rate":"10-20","effect":"Gastrointestinal upset"},{"rate":"5-15","effect":"Dyspepsia"},{"rate":"5-10","effect":"Nausea"},{"rate":"5-10","effect":"Headache"},{"rate":"3-5","effect":"Dizziness"},{"rate":null,"effect":"Increased cardiovascular risk"},{"rate":null,"effect":"Renal impairment risk"}]},"_chembl":{"chemblId":"CHEMBL2108778","moleculeType":"Vaccine component"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that non-selectively inhibits COX-1 and COX-2 enzymes. By blocking prostaglandin production, it reduces inflammatory mediators and provides analgesic and anti-inflammatory effects. This combination study pairs diclofenac with placebo to evaluate its efficacy in a clinical trial setting.","oneSentence":"Diclofenac inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation and pain.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:44:38.937Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute pain"},{"name":"Inflammatory conditions"},{"name":"Rheumatoid arthritis"}]},"trialDetails":[{"nctId":"NCT06566794","phase":"NA","title":"KF2022#4-trial: Effects of a Beta Blocker and NSAID on CYP Mediated Drug Metabolism","status":"COMPLETED","sponsor":"Helsinki University Central Hospital","startDate":"2024-08-22","conditions":"Drug Interaction","enrollment":12},{"nctId":"NCT06298383","phase":"NA","title":"The Effect of Three Different Medications on Anesthetic Success and Postoperative Pain","status":"RECRUITING","sponsor":"Cairo University","startDate":"2025-06-15","conditions":"Symptomatic Irreversible Pulpitis","enrollment":120},{"nctId":"NCT06937853","phase":"NA","title":"Effect of Genetic Polymorphisms on Response to Preoperative NSAIDs in Endodontic Postoperative Pain Management","status":"RECRUITING","sponsor":"Ataturk University","startDate":"2024-05-10","conditions":"Postoperative Pain","enrollment":200},{"nctId":"NCT02193620","phase":"PHASE2, PHASE3","title":"Study of PHN131 in Patients After Surgery","status":"COMPLETED","sponsor":"PhytoHealth Corporation","startDate":"2013-04-30","conditions":"Analgesia Disorder","enrollment":106},{"nctId":"NCT04611529","phase":"PHASE4","title":"Acute Low Back Pain. Topical Diclofenac and Oral Ibuprofen.","status":"COMPLETED","sponsor":"Montefiore Medical Center","startDate":"2021-03-02","conditions":"Low Back Pain","enrollment":198},{"nctId":"NCT05413096","phase":"EARLY_PHASE1","title":"Combination of Diclofenac Potassium and Propolis in the Therapy of Oral Aphthosis","status":"COMPLETED","sponsor":"Al-Azhar University","startDate":"2021-06-01","conditions":"Oral Mucositis, ORAS, Oral Infection","enrollment":100},{"nctId":"NCT04199572","phase":"PHASE4","title":"Synergistic Effect Of Parenteral Diclofenac And Paracetamol In The Pain Management Of Acute Limb Injuries","status":"COMPLETED","sponsor":"Hamad Medical Corporation","startDate":"2022-10-16","conditions":"Musculoskeletal Injury","enrollment":162},{"nctId":"NCT05626140","phase":"PHASE3","title":"COMPARISON OF EFFICACY OF DIFFERENT DRUG COMBINATIONS IN ACUTE SCIATICA","status":"COMPLETED","sponsor":"Pakistan Institute of Medical Sciences","startDate":"2021-09-28","conditions":"Sciatica Acute, Sciatica","enrollment":120},{"nctId":"NCT04500509","phase":"NA","title":"Diclofenac Potassium With or Without Vaginal Dinoprostone Prior to Hysterosalpingography","status":"COMPLETED","sponsor":"Aswan University Hospital","startDate":"2020-09-01","conditions":"Infertility, Female","enrollment":200},{"nctId":"NCT03529097","phase":"PHASE4","title":"Evaluation of the Roll of IV Fluids in the Treatment of Renal Colic","status":"WITHDRAWN","sponsor":"Sheba Medical Center","startDate":"2018-06-01","conditions":"Renal Colic","enrollment":""},{"nctId":"NCT03380533","phase":"PHASE2, PHASE3","title":"Buprenorphine Transdermal Patches in Arthroscopic Rotator Cuff Repair","status":"COMPLETED","sponsor":"Hospital Italiano de Buenos Aires","startDate":"2016-09-22","conditions":"Rotator Cuff Tear, Rotator Cuff Injury, Analgesics, Opioid","enrollment":50},{"nctId":"NCT00864097","phase":"PHASE3","title":"Analgesic Efficacy And Safety of Tanezumab Added On To Diclofenac SR In Patients With Osteoarthritis Of The Knee Or Hip","status":"TERMINATED","sponsor":"Pfizer","startDate":"2009-08-11","conditions":"Osteoarthritis","enrollment":607},{"nctId":"NCT02666846","phase":"PHASE1","title":"Assess the Efficacy and Safety in Volunteers of DCF100, TIB200 and SPR300 vs. Placebo and Control(s) in a UV Pain Model","status":"COMPLETED","sponsor":"Futura Medical Developments Ltd.","startDate":"2015-03","conditions":"Pain","enrollment":60},{"nctId":"NCT04608981","phase":"PHASE4","title":"Effect of Diclofenac Potassium Versus Prednisolone on Post-endodontic Pain and Pulpal IL-8 Expression","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2021-03","conditions":"Symptomatic Irreversible Pulpitis","enrollment":36},{"nctId":"NCT02985671","phase":"PHASE3","title":"To Evaluate the Superiority of Fixed Combination (Orfenadrine 35mg, Acetaminophen 325mg, Caffeine 65mg and Diclofenac Sodium 50mg) Compared to Voltaren® (Diclofenac Sodium 50mg) in the Treatment of Acute Postural Low Back Pain.","status":"UNKNOWN","sponsor":"Ache Laboratorios Farmaceuticos S.A.","startDate":"2021-01","conditions":"Postural Low Back Pain, Mechanical Low Back Pain","enrollment":110},{"nctId":"NCT01263652","phase":"NA","title":"Patient Preferences, Analgesic Delivery Method and Pain Reduction in Spine Patients","status":"WITHDRAWN","sponsor":"Western Galilee Hospital-Nahariya","startDate":"2010-12-31","conditions":"Pain Relief","enrollment":""},{"nctId":"NCT02528188","phase":"PHASE3","title":"Long Term Safety and Efficacy Study of Tanezumab in Subjects With Osteoarthritis of the Hip or Knee","status":"COMPLETED","sponsor":"Pfizer","startDate":"2015-07-21","conditions":"Chronic Pain, Osteoarthritis, Hip, Osteoarthritis, Knee","enrollment":3021},{"nctId":"NCT02255045","phase":"PHASE2, PHASE3","title":"Assessment of a Vaginal Ring With Meloxicam in the Treatment of Dysmenorrhea","status":"COMPLETED","sponsor":"Laboratorios Andromaco S.A.","startDate":"2014-06-27","conditions":"Dysmenorrhea","enrollment":68},{"nctId":"NCT02428777","phase":"PHASE3","title":"Tramadol Versus Diclofenac for Prevention of Pain in Operative Outpatient Hysteroscopy","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2015-04","conditions":"Pain","enrollment":210},{"nctId":"NCT03745599","phase":"PHASE4","title":"Evaluation of the Effects of Different Analgesics on Pericoronitis Pain and Quality of Life","status":"COMPLETED","sponsor":"Near East University, Turkey","startDate":"2017-11-01","conditions":"Pain, Quality of Life","enrollment":60},{"nctId":"NCT02598102","phase":"PHASE2","title":"Efficacy of Preprocedural Diclofenac in Males Undergoing Double J Stent Removal Under Local Anesthesia","status":"COMPLETED","sponsor":"Institute of Nephro Urology, Bangalore","startDate":"2015-04","conditions":"Pain","enrollment":150},{"nctId":"NCT03506763","phase":"PHASE4","title":"Effect of Pre-medication in Pain Measures on Office Hysteroscopy","status":"UNKNOWN","sponsor":"Hospital de Clinicas de Porto Alegre","startDate":"2017-08-01","conditions":"Pain","enrollment":231},{"nctId":"NCT03472339","phase":"PHASE4","title":"Clinical Trial Comparing Intravenous and Oral Diclofenac and Pharmacokinetics","status":"UNKNOWN","sponsor":"Hamad Medical Corporation","startDate":"2018-01-15","conditions":"Pain Management, Limb Injury","enrollment":300},{"nctId":"NCT02714699","phase":"PHASE2, PHASE3","title":"Oral Hyoscine Butyl Bromide Versus Diclofenac Potassium Before Office Hysteroscopy","status":"COMPLETED","sponsor":"Assiut University","startDate":"2016-10","conditions":"Endoscopy","enrollment":129},{"nctId":"NCT03163420","phase":"PHASE2, PHASE3","title":"Diclofenac Potassium on IANB Efficacy in Symptomatic Irreversible Pulpitis","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2016-07","conditions":"Irreversible Pulpitis","enrollment":68},{"nctId":"NCT02709590","phase":"PHASE3","title":"Diclofenac Potassium With Lidocaine Cream in Reducing Pain During HSG","status":"COMPLETED","sponsor":"Assiut University","startDate":"2016-03","conditions":"Pain Relief With HSG","enrollment":140},{"nctId":"NCT03116672","phase":"NA","title":"The Outcome of Preoperative Administration of Single-dose Ketorolac, Non-steroidal Anti-inflammatory Drug and Placebo","status":"COMPLETED","sponsor":"Universidad Autonoma de Baja California","startDate":"2016-02-02","conditions":"Pulpitis - Irreversible","enrollment":3},{"nctId":"NCT02419651","phase":"PHASE3","title":"Tramadol Versus Diclofenac for Reducing Pain Before Outpatient Hysteroscopy","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2015-04","conditions":"Pain, Post Procedural, Pain, Procedural","enrollment":210},{"nctId":"NCT02425709","phase":"PHASE3","title":"Tramadol Versus Diclofenac for Reducing Pain Before Outpatient Hysteroscopy in Post Menopausal Women","status":"UNKNOWN","sponsor":"Cairo 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Used for Acute pain, Inflammatory conditions, Rheumatoid arthritis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}