Progesterone receptor — Drug Target

All drugs that target Progesterone receptor — marketed and clinical-stage. Includes 33 drug classes acting on this target.

Drug classes

Progestin · Progesterone supplement · Estrogen [EPC] · dydrogesterone · Estrogen Receptor Antagonist [EPC] · Progestin (synthetic) · Progestin; Long-acting reversible contraceptive (LARC) · Progestin-only oral contraceptive (minipill) · Progestin; long-acting reversible contraceptive · Progestin contraceptive · Progestin; hormonal contraceptive · Progestin-releasing intrauterine device (IUD)

Marketed (40)

• Vaginal Progesterone · University of North Carolina, Chapel Hill · Progestin · Obstetrics/Gynecology
  Vaginal progesterone supplements the natural hormone progesterone to support and maintain pregnancy by promoting endometrial secretion and reducing uterine contractility.
• Lutinus + transfer day 7 · Anja Bisgaard Pinborg · Progesterone supplement · Reproductive Medicine / Fertility
  Lutinus is a progesterone supplement used to support luteal phase function and embryo implantation during assisted reproductive technology cycles.
• Aygestin · Duramed Res · Estrogen [EPC] · Dermatology
• Gynorest · Solvay · dydrogesterone · Other
• Faslodex · AstraZeneca · Estrogen Receptor Antagonist [EPC] · Oncology
  Faslodex works by binding to and degrading the estrogen receptor, preventing it from promoting the growth of cancer cells.
• Jadelle · Fdn Consumer · Progestin · Bone
  Jadelle works by binding to the progesterone receptor, which helps to prevent ovulation and thicken cervical mucus to prevent sperm from reaching the egg.
• Medroxyprogesterone 17-Acetate · Women's Health Care Clinic, Torrance, California · Progestin · Women's Health / Contraception / Hormone Replacement
  Medroxyprogesterone acetate is a synthetic progestin that suppresses gonadotropin-releasing hormone (GnRH) and inhibits ovulation by acting on the hypothalamic-pituitary-ovarian axis.
• Dydrogesterone M ( case 2 ) · Trieu, Nguyen Thi, M.D. · Progestin · Obstetrics/Gynecology
  Dydrogesterone is a synthetic progestin that binds to progesterone receptors to support luteal phase function and maintain pregnancy.
• Vaginal Progesteron · Omar Mamdouh Shaaban · Progestin · Obstetrics/Gynecology
  Vaginal progesterone delivers the hormone progesterone directly to the reproductive tract to support luteal phase function and maintain early pregnancy.
• LNG · FHI 360 · Progestin (synthetic) · Contraception
  LNG (levonorgestrel) is a synthetic progestin that prevents pregnancy by suppressing ovulation and altering cervical mucus and endometrial conditions.
• Depo Medroxyprogesterone acetate · University of California, San Diego · Progestin; Long-acting reversible contraceptive (LARC) · Contraception; Reproductive Health
  Depo-medroxyprogesterone acetate (DMPA) is a synthetic progestin that prevents pregnancy by suppressing ovulation and thickening cervical mucus.
• Cerazette® · University Hospital, Ghent · Progestin-only oral contraceptive (minipill) · Contraception
  Cerazette is a progestin-only oral contraceptive that prevents pregnancy primarily by thickening cervical mucus and inhibiting ovulation.
• Dydrogesterone Oral Tablet · Kasr El Aini Hospital · Progestin · Obstetrics and Gynecology
  Dydrogesterone is a synthetic progestin that binds to progesterone receptors to support luteal phase function and maintain pregnancy.
• Depo-subQ Provera · Teva Branded Pharmaceutical Products R&D, Inc. · Progestin; long-acting reversible contraceptive · Contraception; Women's Health
  Depo-subQ Provera is a progestin that suppresses the luteinizing hormone surge, preventing ovulation and providing contraceptive efficacy.
• etonogestrel-releasing implant contraceptive · University of Sao Paulo · Progestin contraceptive · Contraception
  Etonogestrel is a progestin that prevents pregnancy by suppressing ovulation and thickening cervical mucus.
• intramuscular depot medroxyprogesterone acetate · Prince of Songkla University · Progestin; hormonal contraceptive · Contraception; Reproductive Health
  Medroxyprogesterone acetate is a synthetic progestin that suppresses gonadotropin-releasing hormone (GnRH) and inhibits ovulation, providing long-acting contraception.
• Levonorgestrel IUS · Oregon Health and Science University · Progestin-releasing intrauterine device (IUD) · Contraception / Gynecology
  Levonorgestrel IUS is an intrauterine system that releases the synthetic progestin levonorgestrel directly into the uterus to prevent pregnancy through multiple mechanisms including cervical mucus thickening, endometrial suppression, and ovulation inhibition.
• Norethindrone acetate (NTA) · Baylor Research Institute · Progestin · Contraception, Gynecology, Endocrinology
  Norethindrone acetate is a synthetic progestin that binds to progesterone receptors to suppress ovulation and alter the endometrium for contraceptive and hormonal therapy effects.
• Natazia · Mochida Pharmaceutical Co., Ltd. · Progestin · Other
  Natazia works by binding to the progesterone receptor in the body, mimicking the effects of the natural hormone progesterone.
• Ortho Evra · Estrogen [EPC] · Metabolic
  Ortho Evra works by binding to the progesterone receptor in the body, mimicking the effects of the natural hormone progesterone.
• Elocon · Merck & Co. · Corticosteroid · Oncology
  Elocon works by binding to the progesterone receptor, which reduces inflammation and immune response in the body.
• Lutinus + transfer day 6 · Anja Bisgaard Pinborg · Progesterone supplement · Reproductive Medicine / Fertility
  Lutinus is a progesterone supplement used to support luteal phase function and embryo implantation during assisted reproductive technology cycles.
• Etonogestrel (ETG) implant · University of Alabama at Birmingham · Progestin contraceptive · Contraception
  Etonogestrel is a progestin that prevents pregnancy by suppressing ovulation and thickening cervical mucus.
• Luteal support with progesterone only · Rabin Medical Center · Hormone replacement therapy · Reproductive Medicine / Fertility
  Progesterone supplementation maintains the secretory endometrium and supports early pregnancy establishment during the luteal phase.
• Norethisterone enantate · London School of Hygiene and Tropical Medicine · Progestin; hormonal contraceptive · Contraception; Reproductive Health
  Norethisterone enantate is a synthetic progestin that suppresses ovulation and alters the endometrium and cervical mucus to prevent pregnancy.
• Implanon® · FHI 360 · Progestin-only contraceptive · Contraception
  Implanon® releases a steady dose of the progestin etonogestrel subdermally to prevent ovulation and thicken cervical mucus, providing long-acting reversible contraception.
• Oral Dienogest · Bio Meds Pharmaceutica Ltda · Progestin · Gynecology
  Dienogest is a synthetic progestin that suppresses ovulation and alters the endometrium to treat endometriosis.
• Depo Provera · University of Alabama at Birmingham · Progestin; long-acting reversible contraceptive · Contraception; Reproductive Health
  Depo-Provera is a long-acting progestin that prevents pregnancy by suppressing ovulation and thickening cervical mucus.
• Plan B (Levonorgestrel) · University of Pennsylvania · Progestin; emergency contraceptive · Contraception / Reproductive Health
  Levonorgestrel is a synthetic progestin that prevents pregnancy primarily by inhibiting or delaying ovulation.
• Noretynodrel · Pfizer · norethynodrel · Other
• transdermal Megace · Milton S. Hershey Medical Center · Progestin; appetite stimulant · Oncology; Palliative care; Cachexia
  Megestrol acetate is a progestin that stimulates appetite and promotes weight gain by acting on the hypothalamus and increasing food intake.
• Depot-Medroxyprogestereone Acetate · University of Southern California · Progestin; Long-acting reversible contraceptive (LARC) · Contraception; Reproductive Health
  Depot-medroxyprogesterone acetate (DMPA) is a synthetic progestin that prevents pregnancy by suppressing ovulation and thickening cervical mucus.
• Depo-Provera Contraceptive Injection - DP150CI · Pfizer · Progestin contraceptive · Contraception
  Depo-Provera is a progestin injection that prevents pregnancy by suppressing ovulation and thickening cervical mucus.
• Levonorgestrel IUD · University of Utah · Progestin-releasing intrauterine device · Contraception / Gynecology
  Levonorgestrel IUD releases a synthetic progestin directly into the uterus to prevent pregnancy through multiple mechanisms including thickening cervical mucus, thinning the endometrium, and inhibiting ovulation.
• MedroxyPROGESTERone Injection [Depo-Provera] · HaEmek Medical Center, Israel · Progestin; Long-acting reversible contraceptive (LARC) · Contraception; Reproductive Health
  Medroxyprogesterone acetate is a synthetic progestin that suppresses gonadotropin-releasing hormone (GnRH), preventing ovulation and altering the endometrium to prevent pregnancy.
• Provera (medroxyprogesterone) · University Hospital of North Norway · Progestin · Gynecology/Contraception
  Medroxyprogesterone is a synthetic progestin that binds to progesterone receptors to suppress ovulation and alter the endometrium.
• NORGESTOMET · Other
• NORETHINDRONE · Estrogen [EPC] · Metabolic
• Dydrogesterone M ( case 1 ) · Trieu, Nguyen Thi, M.D. · Progestin · Obstetrics/Gynecology
  Dydrogesterone is a synthetic progestin that binds to progesterone receptors to support luteal phase function and maintain pregnancy.
• Subcutaneous depot medroxyprogesterone acetate · Planned Parenthood Federation of America · Progestin contraceptive · Contraception
  Medroxyprogesterone acetate is a synthetic progestin that prevents pregnancy by suppressing ovulation and altering the uterine environment.

Phase 3 pipeline (21)

• PP6M injection Dose 1 · Janssen Research & Development, LLC · Progestin-only injectable contraceptive · Contraception / Women's Health
  PP6M is a long-acting injectable contraceptive that prevents pregnancy through hormonal suppression of ovulation.
• PGL4001, progestin, drug free period · PregLem SA · Progestin / Selective Progesterone Receptor Modulator · Contraception / Women's Health
  PGL4001 is a selective progesterone receptor modulator that provides contraceptive and menstrual regulation effects through progestin activity with a structured drug-free period.
• Ulipristal Acetate - open label · PregLem SA · Selective progesterone receptor modulator · Reproductive health
  Ulipristal acetate is a selective progesterone receptor modulator that acts as an antagonist to progesterone.
• Desogestrel late follicular phase · Centre Hospitalier Intercommunal Creteil · Progestin (hormonal contraceptive) · Contraception / Reproductive Health
  Desogestrel is a progestin that prevents pregnancy by suppressing ovulation and altering cervical mucus and endometrial conditions.
• Desogestrel ovulatory phase · Centre Hospitalier Intercommunal Creteil · Progestin (hormonal contraceptive) · Contraception / Reproductive Health
  Desogestrel is a progestin that prevents ovulation by suppressing the luteinizing hormone surge and thickening cervical mucus to inhibit sperm penetration.
• Transdermal system containing progestin · Mylan Pharmaceuticals Inc · Progestin contraceptive / Hormone replacement therapy · Contraception / Women's Health
  A transdermal progestin delivery system that releases the hormone through the skin to provide contraceptive and/or hormone replacement effects.
• Levonorgestrel (BAY98-7196) · Bayer · Progestin · Contraception
  Levonorgestrel is a synthetic progestin that prevents pregnancy by suppressing ovulation and altering cervical mucus and endometrial conditions.
• Desogestrel medium follicular phase · Centre Hospitalier Intercommunal Creteil · Progestin (hormonal contraceptive) · Contraception / Reproductive Health
  Desogestrel is a progestin that prevents pregnancy by suppressing ovulation and altering cervical mucus and endometrial conditions.
• Radiopaque Etonogestrel Implant · Organon and Co · Progestin-only contraceptive · Contraception / Women's Health
  A subdermal contraceptive implant that releases etonogestrel (a progestin) to prevent ovulation and thicken cervical mucus, with added radiopaque material for improved visibility on imaging.
• Radiopaque Implanon · Organon and Co · Progestin-only contraceptive · Contraception
  Radiopaque Implanon is a subdermal contraceptive implant containing etonogestrel that provides long-acting reversible contraception by suppressing ovulation through progestin delivery.
• Crinone8 · University Magna Graecia · Progesterone replacement therapy · Reproductive/Fertility
  Crinone is a progesterone vaginal gel that delivers micronized progesterone directly to the reproductive tract to support luteal phase function and early pregnancy.
• Add-back · ObsEva SA · Progestin (add-back therapy component) · Gynecology / Reproductive Health
  Add-back is a progestin (norethisterone acetate) co-administered with a GnRH agonist to mitigate hypogonadal side effects while maintaining the therapeutic benefits of GnRH suppression.
• Progesterone Soft Capsules · Changchun GeneScience Pharmaceutical Co., Ltd. · Progestogen · Gynecology
  Progesterone is a naturally occurring steroid hormone that plays a crucial role in the menstrual cycle and in maintaining the early stages of pregnancy.
• Desogestrel early follicular phase · Centre Hospitalier Intercommunal Creteil · Progestin (hormonal contraceptive) · Contraception / Reproductive Health
  Desogestrel is a progestin that prevents pregnancy by suppressing ovulation and altering cervical mucus and endometrial conditions.
• Norethindrone Acetate (NA) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) · Progestin · Reproductive Health / Contraception
  Norethindrone acetate is a synthetic progestin that suppresses the luteinizing hormone surge and inhibits ovulation by acting on the hypothalamic-pituitary-ovarian axis.
• intravaginal prasterone · Lee's Pharmaceutical Limited · Progesterone · Gynecology
  Intravaginal prasterone is a vaginal progesterone that mimics the natural hormone progesterone to treat symptoms of menopause.
• mifegyne and cytotec · Western Galilee Hospital-Nahariya · Antiprogestogen · Women's health
  Mifepristone blocks progesterone receptors, while misoprostol induces uterine contractions.
• Desogestrel luteal phase · Centre Hospitalier Intercommunal Creteil · Progestin (hormonal contraceptive) · Contraception / Reproductive Health
  Desogestrel is a progestin that prevents pregnancy by suppressing ovulation and altering cervical mucus and endometrial conditions.
• Minisiston (SH D00342A) · Bayer · Progestin-only oral contraceptive (POP) · Contraception
  Minisiston is a progestin-only oral contraceptive that prevents pregnancy primarily through cervical mucus thickening and endometrial suppression.
• Provera 10 mg. · Instituto Valenciano de Infertilidad, IVI VALENCIA · Progestin (synthetic progesterone) · Contraception / Reproductive Health
  Provera (medroxyprogesterone acetate) is a synthetic progestin that suppresses gonadotropin secretion and inhibits ovulation by acting on the hypothalamic-pituitary-ovarian axis.
• Ulipristal acetate (UPA) · Allergan · Selective progesterone receptor modulator · Women's health
  Ulipristal acetate acts as a selective progesterone receptor modulator (SPRM) to prevent ovulation and thicken cervical mucus, thereby inhibiting sperm penetration.

Phase 2 pipeline (2)

• QUINGESTANOL ACETATE · quingestanol acetate · Other
  Quingestanol acetate works by binding to the progesterone receptor, mimicking the effects of progesterone to prevent ovulation and fertilization.
• Etonogestrel-releasing IUS · Organon and Co · Progesterone receptor agonist · Women's Health
  Etonogestrel-releasing IUS works by releasing a hormone that prevents ovulation and thickens cervical mucus to prevent sperm from reaching the egg.

Phase 1 pipeline (1)

• Additional vaginal progesterone · Hillel Yaffe Medical Center · Progestin · Gynecology
  Progesterone acts on the progesterone receptor.