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MedroxyPROGESTERone Injection [Depo-Provera]
Medroxyprogesterone acetate is a synthetic progestin that suppresses gonadotropin-releasing hormone (GnRH), preventing ovulation and altering the endometrium to prevent pregnancy.
Medroxyprogesterone acetate is a synthetic progestin that suppresses gonadotropin-releasing hormone (GnRH), inhibiting ovulation and altering the endometrium to prevent pregnancy. Used for Contraception (prevention of pregnancy), Management of endometriosis-related pain, Abnormal uterine bleeding.
At a glance
| Generic name | MedroxyPROGESTERone Injection [Depo-Provera] |
|---|---|
| Sponsor | HaEmek Medical Center, Israel |
| Drug class | Progestin; Long-acting reversible contraceptive (LARC) |
| Target | Progesterone receptor |
| Modality | Small molecule |
| Therapeutic area | Contraception; Reproductive Health |
| Phase | FDA-approved |
Mechanism of action
As a long-acting reversible contraceptive, medroxyprogesterone acetate works by inhibiting the luteinizing hormone (LH) surge necessary for ovulation, thickening cervical mucus to impede sperm transport, and thinning the endometrium. When administered as an intramuscular injection (Depo-Provera), it provides contraceptive efficacy for approximately 12 weeks per dose. The drug also has therapeutic applications in hormone-responsive conditions due to its progestin activity.
Approved indications
- Contraception (prevention of pregnancy)
- Endometriosis-related pain
- Abnormal uterine bleeding
Common side effects
- Irregular bleeding or amenorrhea
- Weight gain
- Headache
- Breast tenderness
- Mood changes
- Delayed return to fertility
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