{"id":"medroxyprogesterone-injection-depo-provera","safety":{"commonSideEffects":[{"rate":"30-50","effect":"Irregular bleeding or amenorrhea"},{"rate":"2-3","effect":"Weight gain"},{"rate":"5-10","effect":"Headache"},{"rate":"5-10","effect":"Breast tenderness"},{"rate":"5","effect":"Mood changes"},{"rate":null,"effect":"Delayed return to fertility"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"As a long-acting reversible contraceptive, medroxyprogesterone acetate works by inhibiting the luteinizing hormone (LH) surge necessary for ovulation, thickening cervical mucus to impede sperm transport, and thinning the endometrium. When administered as an intramuscular injection (Depo-Provera), it provides contraceptive efficacy for approximately 12 weeks per dose. The drug also has therapeutic applications in hormone-responsive conditions due to its progestin activity.","oneSentence":"Medroxyprogesterone acetate is a synthetic progestin that suppresses gonadotropin-releasing hormone (GnRH), preventing ovulation and altering the endometrium to prevent pregnancy.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:54:16.763Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Contraception (prevention of pregnancy)"},{"name":"Endometriosis-related pain"},{"name":"Abnormal uterine bleeding"}]},"trialDetails":[],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":15,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"MedroxyPROGESTERone Injection [Depo-Provera]","genericName":"MedroxyPROGESTERone Injection [Depo-Provera]","companyName":"HaEmek Medical Center, Israel","companyId":"haemek-medical-center-israel","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Medroxyprogesterone acetate is a synthetic progestin that suppresses gonadotropin-releasing hormone (GnRH), inhibiting ovulation and altering the endometrium to prevent pregnancy. Used for Contraception (prevention of pregnancy), Management of endometriosis-related pain, Abnormal uterine bleeding.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}