Last reviewed · How we verify
Norethindrone Acetate (NA)
Norethindrone acetate is a synthetic progestin that suppresses the luteinizing hormone surge and inhibits ovulation by acting on the hypothalamic-pituitary-ovarian axis.
Norethindrone acetate is a synthetic progestin that suppresses the luteinizing hormone surge and inhibits ovulation by acting on the hypothalamic-pituitary-ovarian axis. Used for Hormonal contraception, Endometriosis, Abnormal uterine bleeding.
At a glance
| Generic name | Norethindrone Acetate (NA) |
|---|---|
| Sponsor | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) |
| Drug class | Progestin |
| Target | Progesterone receptor |
| Modality | Small molecule |
| Therapeutic area | Reproductive Health / Contraception |
| Phase | Phase 3 |
Mechanism of action
As a progestin, norethindrone acetate binds to progesterone receptors in the hypothalamus and pituitary gland, preventing the release of gonadotropin-releasing hormone (GnRH) and subsequently suppressing luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This suppression of the LH surge prevents ovulation and alters the endometrium, making it unsuitable for implantation. It is commonly used in hormonal contraception and hormone replacement therapy.
Approved indications
- Hormonal contraception
- Endometriosis
- Abnormal uterine bleeding
Common side effects
- Headache
- Nausea
- Breast tenderness
- Irregular bleeding
- Weight changes
Key clinical trials
- Data Analyses for Ancillary WISE Femhrt Hormone Replacement Study (NA)
- Study of Safety and Efficacy of an Oral Contraceptive (PHASE3)
- Treatment of Endometriosis With Norethindrone Acetate ( NA) VS. Gonadotropin- Releasing Hormone (GnRH) Agonist (Lupron Depot 11.25 mg) (PHASE3)
Primary sources
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| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |