{"id":"norethindrone-acetate-na","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Breast tenderness"},{"rate":null,"effect":"Irregular bleeding"},{"rate":null,"effect":"Weight changes"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"As a progestin, norethindrone acetate binds to progesterone receptors in the hypothalamus and pituitary gland, preventing the release of gonadotropin-releasing hormone (GnRH) and subsequently suppressing luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This suppression of the LH surge prevents ovulation and alters the endometrium, making it unsuitable for implantation. It is commonly used in hormonal contraception and hormone replacement therapy.","oneSentence":"Norethindrone acetate is a synthetic progestin that suppresses the luteinizing hormone surge and inhibits ovulation by acting on the hypothalamic-pituitary-ovarian axis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:50:32.006Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hormonal contraception"},{"name":"Endometriosis"},{"name":"Abnormal uterine bleeding"}]},"trialDetails":[{"nctId":"NCT00600106","phase":"NA","title":"Data Analyses for Ancillary WISE Femhrt Hormone Replacement Study","status":"COMPLETED","sponsor":"Cedars-Sinai Medical Center","startDate":"1999-12","conditions":"Myocardial Ischemia","enrollment":37},{"nctId":"NCT00932321","phase":"PHASE3","title":"Study of Safety and Efficacy of an Oral Contraceptive","status":"COMPLETED","sponsor":"Warner Chilcott","startDate":"2004-01","conditions":"Prevention of Pregnancy","enrollment":938},{"nctId":"NCT00458458","phase":"PHASE3","title":"Treatment of Endometriosis With Norethindrone Acetate ( NA) VS. Gonadotropin- Releasing Hormone (GnRH) Agonist (Lupron Depot 11.25 mg)","status":"UNKNOWN","sponsor":"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","startDate":"2004-08","conditions":"Endometriosis, Dysmenorrhea, Dyspareunia","enrollment":112}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":27,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Norethindrone Acetate (NA)","genericName":"Norethindrone Acetate (NA)","companyName":"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","companyId":"eunice-kennedy-shriver-national-institute-of-child-health-and-human-development","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Norethindrone acetate is a synthetic progestin that suppresses the luteinizing hormone surge and inhibits ovulation by acting on the hypothalamic-pituitary-ovarian axis. Used for Hormonal contraception, Endometriosis, Abnormal uterine bleeding.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}