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Luteal support with progesterone only

Rabin Medical Center · FDA-approved active Small molecule

Progesterone supplementation maintains the secretory endometrium and supports early pregnancy establishment during the luteal phase.

Progesterone supplementation maintains the secretory endometrium and supports early pregnancy establishment during the luteal phase. Used for Luteal phase support in assisted reproductive technology (ART) cycles, Prevention of implantation failure and early pregnancy loss in IVF/ICSI cycles.

At a glance

Generic nameLuteal support with progesterone only
SponsorRabin Medical Center
Drug classHormone replacement therapy
TargetProgesterone receptor
ModalitySmall molecule
Therapeutic areaReproductive Medicine / Fertility
PhaseFDA-approved

Mechanism of action

Progesterone is a naturally occurring steroid hormone essential for preparing and maintaining the uterine lining (endometrium) for embryo implantation and early pregnancy maintenance. In assisted reproductive technology (ART) cycles, exogenous progesterone is administered after ovulation to compensate for inadequate corpus luteum function and ensure adequate endometrial receptivity. This luteal phase support reduces the risk of implantation failure and early pregnancy loss.

Approved indications

Common side effects

Key clinical trials

Primary sources

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SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results