{"id":"luteal-support-with-progesterone-only","safety":{"commonSideEffects":[{"rate":null,"effect":"Breast tenderness"},{"rate":null,"effect":"Bloating"},{"rate":null,"effect":"Mood changes"},{"rate":null,"effect":"Injection site reactions (if administered intramuscularly)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Progesterone is a naturally occurring steroid hormone essential for preparing and maintaining the uterine lining (endometrium) for embryo implantation and early pregnancy maintenance. In assisted reproductive technology (ART) cycles, exogenous progesterone is administered after ovulation to compensate for inadequate corpus luteum function and ensure adequate endometrial receptivity. This luteal phase support reduces the risk of implantation failure and early pregnancy loss.","oneSentence":"Progesterone supplementation maintains the secretory endometrium and supports early pregnancy establishment during the luteal phase.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:53:42.786Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Luteal phase support in assisted reproductive technology (ART) cycles"},{"name":"Prevention of implantation failure in in vitro fertilization (IVF)"}]},"trialDetails":[{"nctId":"NCT04806919","phase":"PHASE3","title":"Luteal Support in Artificial Vitrified/Warmed Cycles With Low Progesterone","status":"COMPLETED","sponsor":"University Hospital, Ghent","startDate":"2021-04-02","conditions":"IVF, Embryo Loss, Luteal Phase Defect","enrollment":87},{"nctId":"NCT06239376","phase":"NA","title":"Artificial Cycle With or Without GnRH Agonist Pre-treatment for Frozen Embryo Transfer in Adenomyosis Patients","status":"RECRUITING","sponsor":"Mỹ Đức Hospital","startDate":"2024-02-19","conditions":"Adenomyosis, IVF, Frozen Embryo Transfer","enrollment":222},{"nctId":"NCT06150703","phase":"PHASE3","title":"Luteal Phase Support With GnRH Agonist After GnRH Agonist Triggering in IVF/ICSI Cycles","status":"RECRUITING","sponsor":"Assistance Publique - 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RCT","status":"COMPLETED","sponsor":"Mansoura Integrated Fertility Center","startDate":"2013-03","conditions":"IVF, Infertility","enrollment":220},{"nctId":"NCT01959464","phase":"PHASE4","title":"Sexual Absorption of Vaginal Progesterone","status":"COMPLETED","sponsor":"Wake Forest University Health Sciences","startDate":"2008-11","conditions":"Infertility, Pregnancy","enrollment":20},{"nctId":"NCT03677336","phase":"PHASE4","title":"Oral Dydrogesterone (OD) Versus Micronized Vaginal Progesterone (MVP) for Luteal Phase Support (LPS) in IVF/ICSI","status":"COMPLETED","sponsor":"CRG UZ Brussel","startDate":"2019-05-01","conditions":"Infertility, Female, Infertility, Genital Diseases, Male","enrollment":30},{"nctId":"NCT03181685","phase":"PHASE4","title":"Patients' Preference for Subcutaneous or Vaginal Progesterone as Luteal Support in IVF/ICSI Cycles","status":"TERMINATED","sponsor":"Andros Day Surgery Clinic","startDate":"2016-12-20","conditions":"Infertility, In Vitro Fertilization","enrollment":60},{"nctId":"NCT02798653","phase":"PHASE3","title":"Evaluation of Different Luteal Phase Support Methods in Patients With Poor Ovarian Response","status":"UNKNOWN","sponsor":"Royan Institute","startDate":"2015-11","conditions":"Infertility","enrollment":210},{"nctId":"NCT02736032","phase":"PHASE3","title":"Cryopreserved-thawed Embryo Transfer With or Without Gonadotropin Releasing Hormone Agonist","status":"COMPLETED","sponsor":"Cairo University","startDate":"2016-03","conditions":"Infertility","enrollment":310},{"nctId":"NCT02148393","phase":"NA","title":"Implantation Enhancement by Elective Cryopreservation of All Viable Embryos","status":"COMPLETED","sponsor":"Universitair Ziekenhuis Brussel","startDate":"2014-05","conditions":"Infertility, OHSS","enrollment":212},{"nctId":"NCT02825290","phase":"PHASE4","title":"Modified Luteal Support for Frozen-Thawed Embryo Transfer - 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